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Titolo:
New perspectives about human laryngeal muscle - Single-fiber analyses and interspecies comparisons
Autore:
Wu, YZ; Crumley, RL; Armstrong, WB; Caiozzo, VJ;
Indirizzi:
Univ Calif Irvine, Coll Med, Dept Orthopaed, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 ept Orthopaed, Irvine, CA 92717 USA Univ Calif Irvine, Coll Med, Dept Otolaryngol Head & Neck Surg, Irvine, CA92717 USA Univ Calif Irvine Irvine CA USA 92717 ad & Neck Surg, Irvine, CA92717 USA Univ Calif Irvine, Coll Med, Dept Physiol & Biophys, Irvine, CA 92717 USA Univ Calif Irvine Irvine CA USA 92717 iol & Biophys, Irvine, CA 92717 USA
Titolo Testata:
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY
fascicolo: 7, volume: 126, anno: 2000,
pagine: 857 - 864
SICI:
0886-4470(200007)126:7<857:NPAHLM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYOSIN HEAVY-CHAIN; POSTERIOR CRICOARYTENOID MUSCLE; HUMAN SKELETAL-MUSCLE; HISTOCHEMICAL-CHARACTERISTICS; SHORTENING VELOCITY; EXPRESSION; ISOFORMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Caiozzo, VJ Univ Calif Irvine, Coll Med, Dept Orthopaed, Med Sci I B-152, Irvine, CA 92717 USA Univ Calif Irvine Med Sci I B-152 Irvine CA USA 92717 2717 USA
Citazione:
Y.Z. Wu et al., "New perspectives about human laryngeal muscle - Single-fiber analyses and interspecies comparisons", ARCH OTOLAR, 126(7), 2000, pp. 857-864

Abstract

Background: In companion studies on canine and rodent laryngeal muscle, weobserved that (1) muscle fibers in both the canine and rodent posterior cricoarytenoid (PCA) muscles have a slower myosin heavy-chain (MyHC) isoform profile than those in the thyroarytenoid (TA) muscle; (2) the muscle fiber composition of PCA and TA muscles in canines and rodents is complex given the presence of so-called hybrid fibers (fibers coexpressing various combinations of MyHC iso forms); (3) the types and proportions of hybrid fibers are both muscle specific and, in some cases, region specific; and (4) the MyHC isoform profile of canine laryngeal muscle appears to be slower than thatof rodent laryngeal muscle, suggesting the possibility that larger mammalshave a slower MyHC isoform profile. Objectives: Given the findings of these companion studies and the fact that very little is known about the MyHC isoform composition of laryngeal muscle fibers, the primary objectives of this study were to determine (1) the types of MyHC isoforms found in the human PCA and TA muscles, (2) if there were regional differences in MyHC isoform composition, (3) if hybrid fibers commonly occur in human laryngeal muscle, and (4) if the MyHC isoform profile of human laryngeal muscle is slower than that of canine and rodent laryngeal muscle. Results and Conclusions: The findings of this study clearly demonstrate that both the PCA and TA muscles in humans express 3 types of MyHC isoforms tie, slow type I, fast type IIA, and fast type IIX MyHC isoforms). At the single-fiber level, there were distinct regional differences and hybrid fibers were a common occurrence. Finally, the data demonstrate that the PCA and TA muscles of humans have a slower MyHC profile than that found in either canine or rodent laryngeal muscle.

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Documento generato il 02/07/20 alle ore 21:25:33