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Titolo:
REPEATED REM-SLEEP DEPRIVATION AFTER CHRONIC HALOPERIDOL ADMINISTRATION IN THE RAT
Autore:
SALINPASCUAL RJ; GARCIAFERREIRO R; MOROLOPEZ ML; BLANCOCENTURION C; DRUCKERCOLIN R;
Indirizzi:
NATL AUTONOMOUS UNIV MEXICO,FAC MED,DEPT FISIOL,APDO POSTAL 70-250 MEXICO CITY 04510 DF MEXICO NATL AUTONOMOUS UNIV MEXICO,INST FISIOL CELULAR,DEPT NEUROCIENCIAS MEXICO CITY 04510 DF MEXICO
Titolo Testata:
Psychopharmacology
fascicolo: 3, volume: 131, anno: 1997,
pagine: 216 - 219
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRAIN;
Keywords:
REM SLEEP DEPRIVATION; HALOPERIDOL; DOPAMINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
R.J. Salinpascual et al., "REPEATED REM-SLEEP DEPRIVATION AFTER CHRONIC HALOPERIDOL ADMINISTRATION IN THE RAT", Psychopharmacology, 131(3), 1997, pp. 216-219

Abstract

Repeated haloperidol administration produces up-regulation of dopamine (DA) receptors. REM sleep deprivation (REMSD) does also, but in addition, has been shown to produce REM sleep rebound. Should DA receptor up-regulation play a role in REM sleep rebound, haloperidol could conceivably have effects similar to those observed following REMSD. This is the central question investigated in this study.: Male Wistar rats were prepared for sleep recordings. They were randomly assigned to the following groups: group 1, REMSD by small platforms (40 h REMSD + 8 h recording); group 2, was the large platform control group (40 h in large platforms + 8 h of recording); group 3, received 2-week daily administration of haloperidol (3 mg/kg, IP) plus REMSD (40 h REMSD + 8 h ofrecording); group 1, 2-week administration of haloperidol(3 mg/kg) without sleep manipulation and at the end 40 h were allowed to elapse, following which 8 h of sleep recordings was carried out. In each group the sleep manipulation and/or sleep recordings were repeated five consecutive times. Repeated REMSD produced increases of REM sleep time after each recovery in group 1. Large platforms did not produce increasesof REM sleep during the recovery trials. The 2-week administration ofhaloperidol plus RER ?SD prevented REM sleep rebound (group 3). The 2-week administration of haloperidol without sleep manipulation (group 3) produced a REM sleep reduction. Dopamine modulation seems not to beimportant for REM sleep rebound. Hypersensitivity of DA receptors developed after REMSD may be an epiphenomenon associated with this sleep manipulation, but seems not to participate in REM sleep enhancement after REMSD.

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Documento generato il 28/03/20 alle ore 10:13:45