Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Glucagon-like peptide-1 in fishes: The liver and beyond
Autore:
Mommsen, TP;
Indirizzi:
Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 2Y2, Canada UnivVictoria Victoria BC Canada V8W 2Y2 ol, Victoria, BC V8W 2Y2, Canada
Titolo Testata:
AMERICAN ZOOLOGIST
fascicolo: 2, volume: 40, anno: 2000,
pagine: 259 - 268
SICI:
0003-1569(200004)40:2<259:GPIFTL>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TELEOST FISH; SOMATOSTATIN RELEASE; BIOLOGICAL-ACTIVITY; ICTALURUS-MELAS; BLACK BULLHEAD; GLP-1 ACTIONS; AMERICAN EEL; GLUCOSE; INSULIN; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Mommsen, TP Univ Victoria, Dept Biochem & Microbiol, Victoria, BC V8W 2Y2,Canada Univ Victoria Victoria BC Canada V8W 2Y2 , BC V8W 2Y2, Canada
Citazione:
T.P. Mommsen, "Glucagon-like peptide-1 in fishes: The liver and beyond", AM ZOOLOG, 40(2), 2000, pp. 259-268

Abstract

The incretin hormone glucagon-like peptide-1 (GLP-1), coencoded and expressed In the proglucagon gene in intestine and endocrine pancreas of all vertebrates, is an important regulator of insulin secretion in the postprandialstate of mammals, Additionally, the hormone acts in concert with insulin to remove glucose from the plasma. In mammalian B cells, lung, intestine andbrain, GLP-1 receptors activate the adenylyl cyclase/cAMP system of message transduction, with ancillary involvement of calcium and inositoitrisphosphate. While the peptide is fairly conserved in vertebrates, the fishes showdramatic biochemical and physiological differences to the situation In mammals and an incretin function in fishes is questionable, Fish GLP-1 acts preferentially on the liver, and recently enterocytes and brain membranes have been shown to be potential targets, GLP-1 actions generally oppose those of insulin and supplant or supplement those of glucagon by activating glycogenolysis, gluconeogenesis and lipolysis in liver and by accelerating glucose transport and curtailing glucose oxidation in enterocytes, In br ain andenterocytes, GLP-1 targets adenylyl cyclase, while in the liver adenylyl cyclase and cAMP play subordinate roles only, Although phospholipase C had been implicated in GLP-1 action, the prevalent route of message transductionin fish liver needs to be elucidated, The unique functional switch of GLP-1 from a hyperglycemic hormone in fish to a glucostatic incretin in mammalsremains a matter of conjecture.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:47:37