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Titolo:
Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program
Autore:
Weiss, ST; Van Natta, ML; Zeiger, RS;
Indirizzi:
Brigham & Womens Hosp, Channing Lab, Boston, MA 02115 USA Brigham & WomensHosp Boston MA USA 02115 nning Lab, Boston, MA 02115 USA Johns Hopkins Ctr Clin Trials, Baltimore, MD USA Johns Hopkins Ctr Clin Trials Baltimore MD USA Trials, Baltimore, MD USA Univ Calif San Diego, Dept Pediat, San Diego, CA 92103 USA Univ Calif San Diego San Diego CA USA 92103 diat, San Diego, CA 92103 USA Kaiser Permanente Med Ctr, San Diego, CA USA Kaiser Permanente Med Ctr San Diego CA USA te Med Ctr, San Diego, CA USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 162, anno: 2000,
pagine: 50 - 56
SICI:
1073-449X(200007)162:1<50:RBIARA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSPECIFIC BRONCHIAL RESPONSIVENESS; RANDOM-POPULATION SAMPLE; RESPIRATORY SYMPTOMS; PULMONARY-FUNCTION; INHALED HISTAMINE; EXPIRATORY FLOW; CHILDREN; HYPERRESPONSIVENESS; METHACHOLINE; REACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Weiss, ST Brigham & Womens Hosp, Channing Lab, 181 Longwood Ave, Boston, MA 02115 USA Brigham & Womens Hosp 181 Longwood Ave Boston MA USA 02115 5 USA
Citazione:
S.T. Weiss et al., "Relationship between increased airway responsiveness and asthma severity in the childhood asthma management program", AM J R CRIT, 162(1), 2000, pp. 50-56

Abstract

The relationship between increased airway responsiveness and asthma severity in children is unclear. The Childhood Asthma Management Program (CAMP) with 1,041 children with mild to moderate asthma offers an opportunity to relate the concentration of methacholine that causes a 20% fall in FEV1 (PC20) to level of lung function, occurrence of respiratory symptoms, duration of disease, and assessment of severity by clinical staff. Decreasing PC20 was found to be associated with lower levels of lung function (prebronchodilator percent predicted FEV1: r = 0.29, beta = 3.5, p < 0.001), the occurrence of chronic asthma symptoms, persistent wheezing (odds ratio [OR] = 1.66, p < 0.001), subjective clinical staff assessment of asthma severity (p < 0.001), and longer duration of asthma (r = -0.11, beta = -0.20, p < 0.002). These data provide evidence that the degree of airway responsiveness is linked to disease severity in children with mild to moderate asthma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/02/20 alle ore 03:15:13