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Titolo:
Effects of cool, dry air stimulation on peripheral lung mechanics in asthma
Autore:
Kaminsky, DA; Bates, JHT; Irvin, CG;
Indirizzi:
Univ Vermont, Coll Med, Dept Mol Physiol & Biophys, Pulm Dis & Crit Care Med Unit, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 e Med Unit, Burlington, VT 05405 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 1, volume: 162, anno: 2000,
pagine: 179 - 186
SICI:
1073-449X(200007)162:1<179:EOCDAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXERCISE-INDUCED ASTHMA; COLLATERAL VENTILATION; STIMULUS; AIRWAYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Kaminsky, DA Univ Vermont, Coll Med, Dept Mol Physiol & Biophys, Pulm Dis & Crit Care Med Unit, Given C-317, Burlington, VT 05405 USA Univ Vermont Given C-317 Burlington VT USA 05405 VT 05405 USA
Citazione:
D.A. Kaminsky et al., "Effects of cool, dry air stimulation on peripheral lung mechanics in asthma", AM J R CRIT, 162(1), 2000, pp. 179-186

Abstract

We have previously demonstrated that peripheral airway resistance (Rp) rises more in asthmatics than in nonasthmatic control subjects after segmentalchallenge with cool, dry air. To better understand this rise in Rp, we used a stop-flow method to measure the decay of segment pressure with time that yielded information on airway resistance (Raw), final plateau pressure (Pp), and peripheral lung compliance (Cp). After stop-flow maneuvers in all seven asthmatics and all seven normal subjects, pressure decayed smoothly without an initial sudden drop. This finding suggests that Raw was negligibleand that the predominant site of flow resistance was the collateral pathways of the obstructed segment. Asthmatics had a significantly higher Pp and lower Cp at baseline than did normal subjects, but neither Pp nor Cp changed after challenge. Pp and Rp were significantly correlated. When interpreted in terms of a single-compartment nonlinear model, we concluded that Rp ispredominantly determined by the resistance of the collateral airways rather than the more proximal airways. We also concluded that, compared with normal subjects, asthmatics have (1) more collateral airway narrowing and closure and lower segmental compliance, and (2) after challenge, increased collateral airway narrowing or closure without a change in compliance of the distal lung parenchyma. These results reflect the fundamental differences in peripheral lung mechanics between asthmatic and nonasthmatic subjects and in their response to directly instilled cool, dry air.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 23:40:13