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Titolo:
The endothelin system in normal human colon
Autore:
Egidy, G; Juillerat-Jeanneret, L; Korth, P; Bosman, FT; Pinet, F;
Indirizzi:
Coll France, INSERM, U36, F-75005 Paris, France Coll France Paris FranceF-75005 nce, INSERM, U36, F-75005 Paris, France CHU Vaudois, Inst Pathol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
fascicolo: 1, volume: 279, anno: 2000,
pagine: G211 - G222
SICI:
0193-1857(200007)279:1<G211:TESINH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; CONVERTING ENZYME-1; VASOCONSTRICTOR PEPTIDE; GASTROINTESTINAL-TRACT; FUNCTIONAL EXPRESSION; ION-TRANSPORT; MESSENGER-RNA; RAT COLON; IN-VITRO; RECEPTORS;
Keywords:
in situ hybridization; immunocytochemistry; endothelial cell; smooth muscle cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Pinet, F Coll France, INSERM, U36, 3 Rue Ulm, F-75005 Paris, France Coll France 3 Rue Ulm Paris France F-75005 F-75005 Paris, France
Citazione:
G. Egidy et al., "The endothelin system in normal human colon", AM J P-GAST, 279(1), 2000, pp. G211-G222

Abstract

Endothelin (ET)-1 is a potent vasoconstrictor and mitogenic peptide that has a variety of biological effects in noncardiovascular tissues. The precise cellular distribution of the ET-1 system in the wall of the normal human colon was studied to identify the physiological role of ET in the gut. In situ hybridization revealed ET-converting enzyme-1 (ECE-1) mRNA in all vessels, the colon epithelium, and macrophages. Prepro-ET-1 (PPET-1) mRNA had a similar distribution except for a scattered signal in mucosal microvessels. ETA and ETB receptor mRNAs were mainly in the lamina propria, pericryptal myofibroblasts, microvessels, and mononuclear cells, with ETA mRNA more abundant than ETB mRNA. I-125-ET-1 binding showed ETB along the crypts and in nerve fibers descending from the ganglionic plexus that contained PPET-1, ECE-1, and ETB transcripts, whereas glia contained ETA receptors. The finding of the entire ET system in the normal mucosa suggests its implication in some characteristic functions of the colon and its secretion as both a neuroactive and a vasoactive peptide.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:35:28