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Titolo:
Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism
Autore:
Gallagher, D; Kovera, AJ; Clay-Williams, G; Agin, D; Leone, P; Albu, J; Matthews, DE; Heymsfield, SB;
Indirizzi:
Columbia Univ, St Lukes Roosevelt Hosp, Obes Res Ctr, Dept Med, New York, NY 10025 USA Columbia Univ New York NY USA 10025 Ctr, Dept Med, New York, NY 10025 USA Univ Vermont, Dept Med, Burlington, VT 05405 USA Univ Vermont Burlington VT USA 05405 , Dept Med, Burlington, VT 05405 USA Univ Vermont, Dept Chem, Burlington, VT 05405 USA Univ Vermont BurlingtonVT USA 05405 Dept Chem, Burlington, VT 05405 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
fascicolo: 1, volume: 279, anno: 2000,
pagine: E124 - E131
SICI:
0193-1849(200007)279:1<E124:WLIPON>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAT-FREE MASS; SKELETAL-MUSCLE MASS; AEROBIC EXERCISE; RISK-FACTORS; OLDER WOMEN; POTASSIUM; AGE; DIET; PREVALENCE; MORTALITY;
Keywords:
obesity treatment; skeletal muscle mass;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Gallagher, D Columbia Univ, St Lukes Roosevelt Hosp, Obes Res Ctr, Dept Med, 1090 Amsterdam Ave, New York, NY 10025 USA Columbia Univ 1090 Amsterdam Ave New York NY USA 10025 25 USA
Citazione:
D. Gallagher et al., "Weight loss in postmenopausal obesity: no adverse alterations in body composition and protein metabolism", AM J P-ENDO, 279(1), 2000, pp. E124-E131

Abstract

We sought to determine if decrements in the mass of fat-free body mass (FFM) and other lean tissue compartments, and related changes in protein metabolism, are appropriate for weight loss in obese older women. Subjects were 14 healthy weight-stable obese (BMI greater than or equal to 30 kg/m(2)) postmenopausal women >55 yr who participated in a 16-wk, 1,200 kcal/day nutritionally complete diet. Measures at baseline and 16 wk included FFM and appendicular lean soft tissue (LST) by dual-energy X-ray absorptiometry; body cell mass (BCM) by K-40 whole body counting; total body water (TBW) by tritium dilution; skeletal muscle (SM) by whole body MRI; and fasting whole body protein metabolism through L-[1-C-13] leucine kinetics. Mean weight loss (+/-SD) was 9.6 +/- 3.0 kg (P< 0.0001) or 10.7% of initial body weight. FFMdecreased by 2.1 +/- 2.6 kg (P = 0.006), or 19.5% of weight loss, and did not differ from that reported (2.3 +/- 0.7 kg). Relative losses of SM, LST,TBW, and BCM were consistent with reductions in body weight and FFM. Changes in [1-C-13] leucine flux, oxidation, and synthesis rates were not significant. Follow-up of 11 subjects at 23.7 +/- 5.7 mo showed body weight and fat mass to be below baseline values; FFM was nonsignificantly reduced. Weight loss was accompanied by body composition and protein kinetic changes that appear appropriate for the magnitude of body mass change, thus failing tosupport the concern that diet-induced weight loss in obese postmenopausal women produces disproportionate LST losses.

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Documento generato il 25/11/20 alle ore 01:32:30