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Titolo:
Trial of oral fumagillin for the treatment of intestinal microsporidiosis in patients with HIV infection
Autore:
Molina, JM; Goguel, J; Sarfati, C; Michiels, JF; Desportes-Livage, I; Balkan, S; Chastang, C; Cotte, L; Maslo, C; Struxiano, A; Derouin, F; Decazes, JM;
Indirizzi:
Hop La Pitie Salpetriere, INSERM,U511, Hop St Louis, Dept Infect Dis, Paris, France Hop La Pitie Salpetriere Paris France s, Dept Infect Dis, Paris, France Hop La Pitie Salpetriere, INSERM,U511, Hop St Louis, Dept Parasitol, Paris, France Hop La Pitie Salpetriere Paris France is, Dept Parasitol, Paris, France Hop La Pitie Salpetriere, INSERM,U511, Hop St Louis, Dept Biostat, Paris, France Hop La Pitie Salpetriere Paris France ouis, Dept Biostat, Paris, France Hop La Pitie Salpetriere, INSERM,U511, Hop St Louis, Clin Invest Ctr, Paris, France Hop La Pitie Salpetriere Paris France s, Clin Invest Ctr, Paris, France Hop Rothschild, F-75571 Paris, France Hop Rothschild Paris France F-75571 op Rothschild, F-75571 Paris, France Hotel Dieu, Nice, France Hotel Dieu Nice FranceHotel Dieu, Nice, France Hotel Dieu, Lyon, France Hotel Dieu Lyon FranceHotel Dieu, Lyon, France Sanofi Rech, Gentilly, France Sanofi Rech Gentilly FranceSanofi Rech, Gentilly, France
Titolo Testata:
AIDS
fascicolo: 10, volume: 14, anno: 2000,
pagine: 1341 - 1348
SICI:
0269-9370(20000707)14:10<1341:TOOFFT>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; ENTEROCYTOZOON-BIENEUSI; METHIONINE AMINOPEPTIDASE-2; ENCEPHALITOZOON-CUNICULI; ANTIRETROVIRAL THERAPY; TOPICAL FUMAGILLIN; IN-VITRO; AIDS; KERATOCONJUNCTIVITIS; ANGIOGENESIS;
Keywords:
AIDS; diarrhoea; fumagillin; Enterocytozoon bieneusi; HIV infection; microsporidiosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Molina, JM Hop St Louis, Clin Malad Infect, 1 Ave Claude Vellefaux, F-75475 Paris 10,France Hop St Louis 1 Ave Claude Vellefaux Paris France 10 10,France
Citazione:
J.M. Molina et al., "Trial of oral fumagillin for the treatment of intestinal microsporidiosis in patients with HIV infection", AIDS, 14(10), 2000, pp. 1341-1348

Abstract

Objective: Intestinal microsporidiosis caused by Enterocytozoon bieneusi is a cause of chronic diarrhoea in patients with HIV infection for which there is no current therapy. This study was designed to assess the safety and efficacy of oral fumagillin in this infection. Design: A dose-escalation trial. Methods: Twenty-nine HIV-infected patients with E. bieneusi infection wereconsecutively enrolled in the trial. Oral doses of fumagillin were given to four groups of patients for 14 days: 10 mg/day (group 1), 20 mg/day (group 2), 40 mg/day (group 3), and 60 mg/day (group 4). Patients were seen at weeks 1, 2, 4 and 6 to assess safety and efficacy. Efficacy was assessed primarily by the the clearance of microsporidia from stools and follow-up duodenal biopsies. Results: Thirteen patients complained of abdominal cramps, vomiting or diarrhoea during the study, and three patients had fumagillin withdrawn because of adverse events. Thrombocytopenia, neutropenia and hyperlipasaemia werethe most frequent biological adverse events. Twenty-one out of 29 patientstransiently cleared microsporidia from their stools during the study. By week 6, however, all patients in groups 1, 2 and 3 had parasitic relapse. Interestingly, eight out of 11 (72%) patients treated with 60 mg/day (group 4) apparently cleared microsporidia from their gastrointestinal tract and gained weight. No parasitic relapse was documented in these eight patients during a mean follow-up of 11.5 months. Conclusion: Treatment with fumagillin at 60 mg/day for 14 days has promiseas an effective oral treatment for E, bieneusi infections, (C) 2000 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:26:58