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Titolo:
NMDA receptor mechanism involved in arterial baroreflex
Autore:
Wang, JJ; Rong, WF; Wang, WZ; Zhang, L; Yuan, WJ;
Indirizzi:
Second Mil Med Univ, Dept Physiol, Shanghai 200433, Peoples R China SecondMil Med Univ Shanghai Peoples R China 200433 433, Peoples R China
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 7, volume: 21, anno: 2000,
pagine: 617 - 622
SICI:
0253-9756(200007)21:7<617:NRMIIA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
AORTIC BARORECEPTOR REFLEXES; NUCLEUS-TRACTUS-SOLITARII; VENTROLATERAL MEDULLA; MEDIATE; INHIBITION; ANTAGONIST; RESPONSES; GLUTAMATE; NEURONS; RATS;
Keywords:
N-methyl-D-aspartate receptors; baroreflex; solitary nucleus; medulla oblongata; excitatory amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Yuan, WJ Second Mil Med Univ, Dept Physiol, Shanghai 200433, Peoples R China Second Mil Med Univ Shanghai Peoples R China 200433 les R China
Citazione:
J.J. Wang et al., "NMDA receptor mechanism involved in arterial baroreflex", ACT PHAR SI, 21(7), 2000, pp. 617-622

Abstract

AIM: To study the roles of N-methyl-D-aspartate (NMDA) receptors in arterial baroreflex. METHODS: Experiments were performed in 17 urethane-anaesthetized male Sprague-Dawly rats. Twenty-seven rostral ventrolateral medulla (RVLM) neurons were electrophysiologically identified as putative presympathetic neurons. Responses of these neurons to baroreflex activation were used as an index to observe the effects of 3-(2-carboxypiperazin-4-yl) propyl-l-phosphonic acid (CPP) microinjected (0.1 mu L, 50 mmol . L-1) into the nucleus tractus solitarii (NTS) or the caudal ventrolateral medulla (NLM) ipsilaterally. RESULTS: In the NTS, CPP eliminated or attenuated the inhibition of these neurons induced by aortic nerve stimulation, but the inhibition induced by elevation of arterial pressure was not eliminated and the cardiac cycle-related rhythm of spontaneous discharge still existed. Whereas in theCVLM, CPP eliminated not only the inhibition of these neurons induced by aortic nerve stimulation, but the inhibition induced by blood pressure elevation and the cardiac cycle-related rhythm of spontaneous discharge disappeared. CONCLUSION: NMDA mechanism is importantly involved in the mechanism ofbaroreflex both in the NTS and in the CVLM; the barosensitive neurons in the NTS project to ipsilateral CVLM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 21:21:49