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Titolo:
The carbohydrate metabolism of Fasciola hepatica, an example of biochemical adaptations in parasitic helminths
Autore:
Tielens, AGM;
Indirizzi:
Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, NL-3508 TD Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TD 3508 TD Utrecht, Netherlands
Titolo Testata:
ACTA PARASITOLOGICA
fascicolo: 2, volume: 45, anno: 2000,
pagine: 59 - 66
SICI:
1230-2821(200004)45:2<59:TCMOFH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUCCINATE-UBIQUINONE OXIDOREDUCTASE; ENERGY-METABOLISM; LIVER FLUKE; COMPLEX-II; SCHISTOSOMA-MANSONI; ESCHERICHIA-COLI; COA TRANSFERASE; ASCARIS-SUUM; RHODOQUINONE; NEMATODE;
Keywords:
Fasciola hepatica; energy metabolism; bioenergetics; fumarate reductase; electron-transport chain; rhodoquinone;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Tielens, AGM Univ Utrecht, Fac Vet Med, Dept Biochem & Cell Biol, POB 80176, NL-3508 TDUtrecht, Netherlands Univ Utrecht POB 80176 Utrecht Netherlands NL-3508 TD rlands
Citazione:
A.G.M. Tielens, "The carbohydrate metabolism of Fasciola hepatica, an example of biochemical adaptations in parasitic helminths", ACT PARASIT, 45(2), 2000, pp. 59-66

Abstract

The energy metabolism of the liver fluke, Fasciola hepatica, offers good examples of adaptations in metabolism in parasitic helminths. Adaptations inthe metabolism of parasitic helminths are twofold. On the one hand, adaptations occur to the fact that for the parasitic stages, the environment (host) provides many substrates that can be used directly for anabolic as well as catabolic purposes. Therefore, parasitic stages have lost (parts of) many of the anabolic pathways common to non-parasitic organisms. On the other hand, parasitic helminths continuously adapt their metabolism to the different environments they encounter during their life cycle, while alternating between free-living and parasitic stages. In this review the carbohydrate metabolism of F. hepatica will be discussed as model system for these adaptations. Adaptations to the parasitic way of life, as well as to the changingenvironment will be presented. Special attention will be paid to transitions in carbohydrate metabolism during the development in the final host, from an aerobic energy metabolism in the juvenile liver fluke to an anaerobic one in the mature adult. Changes in the electron-transport chain, includingthe quinone used in the different types of metabolism, will also be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:19:39