Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro
Autore:
Meerts, IATM; van Zanden, JJ; Luijks, EAC; van Leeuwen-Bol, I; Marsh, G; Jakobsson, E; Bergman, A; Brouwer, A;
Indirizzi:
Wageningen Univ & Res Ctr, Toxicol Grp, Dept Food Technol & Nutr Sci, NL-6703 HE Wageningen, Netherlands Wageningen Univ & Res Ctr Wageningen Netherlands NL-6703 HE Netherlands Stockholm Univ, Wallenberg Lab, Dept Environm Chem, S-10691 Stockholm, Sweden Stockholm Univ Stockholm Sweden S-10691 Chem, S-10691 Stockholm, Sweden Free Univ Amsterdam, Inst Environm Studies, NL-1007 MC Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands NL-1007 MC terdam, Netherlands
Titolo Testata:
TOXICOLOGICAL SCIENCES
fascicolo: 1, volume: 56, anno: 2000,
pagine: 95 - 104
SICI:
1096-6080(200007)56:1<95:PCIOSB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYBROMINATED DIPHENYL ETHERS; THYROID-HORMONE LEVELS; THYROXINE BINDING-SITES; POLYCHLORINATED-BIPHENYLS; PRE-ALBUMIN; RAT-LIVER; 3,4,3',4'-TETRACHLOROBIPHENYL; METABOLITES; GLOBULIN; PROTEIN;
Keywords:
brominated flame retardants; transthyretin; structure-activity relationship;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Meerts, IATM Wageningen Univ & Res Ctr, Toxicol Grp, Dept Food Technol & Nutr Sci, Tuinlaan 5, NL-6703 HE Wageningen, Netherlands Wageningen Univ & Res Ctr Tuinlaan 5 Wageningen Netherlands NL-6703 HE
Citazione:
I.A.T.M. Meerts et al., "Potent competitive interactions of some brominated flame retardants and related compounds with human transthyretin in vitro", TOXICOL SCI, 56(1), 2000, pp. 95-104

Abstract

Brominated flame retardants such as polybrominated diphenyl ethers (PBDEs), pentabromophenol (PBP), and tetrabromobisphenol A (TBBPA) are produced inlarge quantities for use in electronic equipment, plastics, and building materials. Because these compounds have some structural resemblance to the thyroid hormone thyroxine (T-4), it was suggested that they may interfere with thyroid hormone metabolism and transport, e.g., by competition with T-4 on transthyretin (TTR). In the present study, we investigated the possible interaction of several brominated flame retardants with T-4 binding to TTR in an in vitro competitive binding assay, using human TTR and I-125-T-4 as the displaceable radioligand. Compounds were tested in at least eight different concentrations ranging from 1.95 to 500 nM. In addition, we investigated the structural requirements of these and related ligands for competitivebinding to TTR. We were able to show very potent competition binding for TBBPA and PBP (10.6- and 7.1-fold stronger than the natural ligand T-4, respectively). PBDEs were able to compete with T-4-TTR binding only after metabolic conversion by induced rat liver microsomes, suggesting an important role for hydroxylation. Brominated bisphenols with a high degree of bromination appeared to be more efficient competitors, whereas chlorinated bisphenols were less potent compared to their brominated analogues. These results indicate that brominated flame retardants, especially the brominated phenols and tetrabromobisphenol A, are very potent competitors for T-4 binding to human transthyretin in vitro and may have effects on thyroid hormone homeostasis in vivo comparable to the thyroid-disrupting effects of PCBs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:54:12