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Titolo:
Thyroid function in children with perinatal human immunodeficiency virus type 1 infection
Autore:
Chiarelli, F; Galli, L; Verrotti, A; di Ricco, L; Vierucci, A; de Martino, M;
Indirizzi:
Univ Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Chieti Chieti Italy iv Chieti, Dept Med, Div Pediat, Chieti, Italy Univ Florence, Dept Pediat, I-50121 Florence, Italy Univ Florence Florence Italy I-50121 ept Pediat, I-50121 Florence, Italy
Titolo Testata:
THYROID
fascicolo: 6, volume: 10, anno: 2000,
pagine: 499 - 505
SICI:
1050-7256(200006)10:6<499:TFICWP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNDROME AIDS; DISEASE PROGRESSION; HORMONE METABOLISM; INFANTS; PUBERTY; RISK; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chiarelli, F Osped Policlin, Pediat Clin, Via Vestini 5, I-66100 Chieti, Italy Osped Policlin Via Vestini 5 Chieti Italy I-66100 eti, Italy
Citazione:
F. Chiarelli et al., "Thyroid function in children with perinatal human immunodeficiency virus type 1 infection", THYROID, 10(6), 2000, pp. 499-505

Abstract

Objective: To study thyroid function in children with perinatal HIV-1 infection retrospectively and determine whether thyroid abnormalities are correlated with clinical condition, disease progression, immunological impairment, and viral load. Study design and setting: Total (TT4) and free (FT3) thyroxine, total (TT3) and free (FT3) triiodothyronine, reverse triiodothyronine (rT(3)), thyrotropin (TSH), thyroglobulin (TG), and thyroid binding globulin (TBG) were measured twice in 56 children with perinatal human immunodeficiency virus type 1 (HIV-1) infection. Median age at first determination was 13.5 (range: 0.03-127.0) months; median age at second determination was66.2 (range 3.42-147.4) months. Antithyroglobulin, antimicrosomal, thyroidperoxidase, and thyrotropin receptor antibodies were also evaluated. Fifty-three healthy children were selected as controls. Results: TT3, TT4, FT4, and TG were significantly reduced and rT(3), TBG, and TSH increased in children with HIV-1 infection when compared with controls. Thyroid dysfunction correlated with severe immunosuppression and high viral load early in life preceded the onset of the disease and worsened over time. Autoantibodies were negative in all children with HIV-1 infection in all determinations. Conclusion: Thyroid abnormalities are observed early in the course of perinatal HIV-1 infection; thyroid dysfunction is particularly pronounced in children with severe immunosuppression and high viral load. Modifications of thyroid function precede worsening of clinical course in HIV-1 infected children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:10:02