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Titolo:
Genetic variants of platelet glycoprotein receptors and risk of stroke in young women
Autore:
Reiner, AP; Kumar, PN; Schwartz, SM; Longstreth, WT; Pearce, RM; Rosendaal, FR; Psaty, BM; Siscovick, DS;
Indirizzi:
Univ Washington, Dept Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ton, Dept Med, Seattle, WA 98195 USA Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 ept Epidemiol, Seattle, WA 98195 USA Univ Washington, Dept Neurol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Neurol, Seattle, WA 98195 USA Univ Washington, Cardiovasc Hlth Res Unit, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Hlth Res Unit, Seattle, WA 98195 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA Univ Leiden Hosp, Ctr Hemostasis & Thrombosis Res, NL-2300 RC Leiden, Netherlands Univ Leiden Hosp Leiden Netherlands NL-2300 RC 00 RC Leiden, Netherlands Univ Leiden Hosp, Dept Clin Epidemiol, NL-2300 RC Leiden, Netherlands UnivLeiden Hosp Leiden Netherlands NL-2300 RC 00 RC Leiden, Netherlands
Titolo Testata:
STROKE
fascicolo: 7, volume: 31, anno: 2000,
pagine: 1628 - 1633
SICI:
0039-2499(200007)31:7<1628:GVOPGR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-V-LEIDEN; MYOCARDIAL-INFARCTION; ISCHEMIC STROKE; CODING SEQUENCE; IB-ALPHA; POLYMORPHISMS; ASSOCIATION; THROMBOSIS; HPA-3; IIIA;
Keywords:
platelets; polymorphism; stroke, hemorrhagic; stroke, ischemic;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Reiner, AP Univ Washington, Dept Med, Box 359756, Seattle, WA 98195 USA Univ Washington Box 359756 Seattle WA USA 98195 e, WA 98195 USA
Citazione:
A.P. Reiner et al., "Genetic variants of platelet glycoprotein receptors and risk of stroke in young women", STROKE, 31(7), 2000, pp. 1628-1633

Abstract

Background and Purpose-A number of studies have examined the relationship between genetic platelet glycoprotein variants and early-onset atherothrombotic disease, particularly acute myocardial infarction. Data on the association of these genetic susceptibility markers with ischemic stroke are more limited, and their role in hemorrhagic stroke has not been previously examined. Methods-We performed genotype analysis for 5 common diallelic platelet glycoprotein polymorphisms in a population-based study of 78 white women aged <45 years with arterial stroke (36 ischemic cases and 42 hemorrhagic cases)and 346 demographically similar control subjects. Results-The 807T variant of glycoprotein Ia was associated with a 2-fold increased risk of ischemic stroke (age-adjusted odds ratio [OR]=2.24; 95% CI=0.99 to 5.06). The Met(145) allele of glycoprotein Iba was associated witha trend toward an increased risk of ischemic stroke that was more pronounced in the homozygous state (OR=10.36), but the CI is extremely wide becauseof the small numbers of subjects (95% CI=1.43 to 79.34). Homozygosity for the Ser(843) allele of the glycoprotein IIb was associated with an approximate to 5-fold increased risk of ischemic stroke among subgroups of women who carried a diagnosis of hypertension of diabetes (OR=4.51; 95% CI=1.01 to 20.13) or had elevated plasma homocysteine levels (OR=5.94; 95% CI=1.53 to 23.05). The genotype distributions for all 5 platelet glycoprotein polymorphisms were similar among hemorrhagic stroke cases and controls. Conclusions-Several inherited platelet glycoprotein variants may be associated with an increased risk of ischemic stroke in young women. These associations seemed to be confined to women with other cardiovascular risk factors. Additional studies involving larger numbers of subjects are needed to confirm these preliminary findings.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:54:22