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Titolo:
Vasodilatory response of border zones to acetazolamide before and after endarterectomy - An echo planar imaging-dynamic susceptibility contrast-enhanced MRI study in patients with high-grade unilateral internal carotid artery stenosis
Autore:
Wiart, M; Berthezene, Y; Adeleine, P; Feugier, P; Trouillas, P; Froment, JC; Nighoghossian, N;
Indirizzi:
INSERM, CNRS Res Unit, UMR 5515, CREATIS, F-69008 Lyon, France INSERM Lyon France F-69008 Unit, UMR 5515, CREATIS, F-69008 Lyon, France UFR Laennec, Lab Informat Med, Lyon, France UFR Laennec Lyon FranceUFR Laennec, Lab Informat Med, Lyon, France Hop Edu Herriot, Dept Vasc Surg, Lyon, France Hop Edu Herriot Lyon France p Edu Herriot, Dept Vasc Surg, Lyon, France Cerebrovasc Dis & Ataxia Res Ctr, Dept Neurol, Lyon, France Cerebrovasc Dis & Ataxia Res Ctr Lyon France Dept Neurol, Lyon, France
Titolo Testata:
STROKE
fascicolo: 7, volume: 31, anno: 2000,
pagine: 1561 - 1565
SICI:
0039-2499(200007)31:7<1561:VROBZT>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; EMISSION COMPUTED-TOMOGRAPHY; HIGH-RESOLUTION MEASUREMENT; TRACER BOLUS PASSAGES; CEREBROVASCULAR-DISEASE; VASOMOTOR REACTIVITY; PATTERNS; SPECT; HEMODYNAMICS; PERFUSION;
Keywords:
acetazolamide; border zone; carotid endarterectomy; carotid stenosis; magnetic resonance imaging;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Wiart, M Hop Neurol Cardiol, CREATIS UMR 5515, Serv Radiol, BP Lyon Montchat, F-69394 Lyon 03, France Hop Neurol Cardiol BP Lyon Montchat Lyon France 03 on 03, France
Citazione:
M. Wiart et al., "Vasodilatory response of border zones to acetazolamide before and after endarterectomy - An echo planar imaging-dynamic susceptibility contrast-enhanced MRI study in patients with high-grade unilateral internal carotid artery stenosis", STROKE, 31(7), 2000, pp. 1561-1565

Abstract

Background and Purpose-The importance of hemodynamic changes related to a high-grade internal carotid artery (ICA) stenosis remains a matter of controversy. Areas between the vascular territories of major cerebral arteries, namely, the border zones, may be selectively vulnerable to hemodynamic alteration. The aim of this study was to search for any hemodynamic impact of carotid endarterectomy (CEA) on vasodilatory response, in particular, withinthe border zones, by means of multislice dynamic susceptibility contrast MRI. Methods-Thirteen patients with a high-grade unilateral ICA stenosis (>80%)were examined. Relative regional cerebral blood volume (rrCBV) was determined separately for white matter, gray matter, and anterior and posterior border zones by the acetazolamide test. A vasomotor reactivity index was evaluated from the rrCBV values, Values from the ipsilateral hemisphere were compared with contralateral ones, before and after CEA. Results-Before CEA, rrCBV values in the anterior border zones were significantly (P<0.05) higher in the ipsilateral hemisphere than in the contralateral hemisphere. A decrease in vasomotor reactivity indexes was also observed in the lesion side, but the difference from the contralateral side was not statistically significant. In posterior border zones, no differences in rrCBV or vasomotor reactivity were found between the ipsilateral and the contralateral hemispheres. After CEA, the rrCBV asymmetry in the anterior border zones cleared. Conclusions-High-grade ICA stenosis with efficient primary collateral pathways may have an early limited hemodynamic impact within border-zone areas. The favorable course of these abnormalities after surgery suggests an additional benefit of CEA at this stage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/09/20 alle ore 20:13:51