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Titolo:
Vascular dementia - Incidence and risk factors in the Canadian Study of Health and Aging
Autore:
Hebert, R; Lindsay, J; Verreault, R; Rockwood, K; Hill, G; Dubois, MF;
Indirizzi:
Univ Sherbrooke, Geriatr Inst, Sherbrooke, PQ J1H 4C4, Canada Univ Sherbrooke Sherbrooke PQ Canada J1H 4C4 erbrooke, PQ J1H 4C4, Canada Hlth Canada, Lab Ctr Dis Control, Ottawa, ON K1A 0L2, Canada Hlth Canada Ottawa ON Canada K1A 0L2 Control, Ottawa, ON K1A 0L2, Canada Univ Laval, Quebec City, PQ, Canada Univ Laval Quebec City PQ CanadaUniv Laval, Quebec City, PQ, Canada Sisters Char Ottawa Hlth Serv Inc, Ottawa, ON, Canada Sisters Char Ottawa Hlth Serv Inc Ottawa ON Canada c, Ottawa, ON, Canada Dalhousie Univ, Halifax, NS, Canada Dalhousie Univ Halifax NS CanadaDalhousie Univ, Halifax, NS, Canada
Titolo Testata:
STROKE
fascicolo: 7, volume: 31, anno: 2000,
pagine: 1487 - 1493
SICI:
0039-2499(200007)31:7<1487:VD-IAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
MULTI-INFARCT DEMENTIA; APOLIPOPROTEIN-E EPSILON-4; ALZHEIMERS-DISEASE; ELDERLY POPULATION; ALLELE FREQUENCY; PREVALENCE; DIAGNOSIS; COMMUNITY; PROJECT; STROKE;
Keywords:
cerebrovascular disorders; epidemiology; cohort; case-control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Hebert, R Gerontol & Geriatr Res Ctr, 1036 Belvedere Sud, Sherbrooke, PQ J1H 4C4, Canada Gerontol & Geriatr Res Ctr 1036 Belvedere Sud Sherbrooke PQ Canada J1H 4C4
Citazione:
R. Hebert et al., "Vascular dementia - Incidence and risk factors in the Canadian Study of Health and Aging", STROKE, 31(7), 2000, pp. 1487-1493

Abstract

Background and Purpose-Very few population-based studies have systematically examined incident vascular dementia (VaD). From the Canadian Study of Health and Aging cohort, incidence rates of VaD were determined and risk factors analyzed. Methods-This was a cohort incidence study that followed 8623 subjects presumed to be free of dementia over a 5-year period. The risk factors were examined with a nested prospective case-control study. Exposure was determinedby means of a risk factor questionnaire administered to the subject or a proxy at the beginning of the study. Results-On the basis of 38 476 person years at risk, the annual incidence rate was estimated to be 2.52 per thousand undemented Canadians (95% CI 2.02 to 3.02). Including an estimation of the probability of VaD among the decedents, this figure rose to 3.79. For the risk factors study, 105 incident cases of VaD according to the NINCDS-AIREN criteria were compared with 802 control subjects. Significant risk factors were: age (OR=1.05), residing ina rural area (2.03), living in an institution (2.33), diabetes (2.15), depression (2.41), apolipoprotein E epsilon 4 (2.34), hypertension for women (2.05), heart problems for men (2.52), taking aspirin (2.33), and occupational exposure to pesticides or fertilizers (2.05). Protective factors were eating shellfish (0.46) and regular exercise for women (0.46). There was no relation with sex, education, or alcohol. Conclusions-The study confirmed some previously reported risk factors but also suggested new ones. It raised concerns about the prescription of aspirin and perhaps other factors related to rural life.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 00:51:32