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Titolo:
Prophylactic oophorectomy: Clinical considerations
Autore:
Gotlieb, WH; Baruch, GB; Friedman, E;
Indirizzi:
Tel Aviv Univ, Chaim Sheba Med Ctr, Div Gynecol Oncol, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 IL-52621 Tel Hashomer, Israel
Titolo Testata:
SEMINARS IN SURGICAL ONCOLOGY
fascicolo: 1, volume: 19, anno: 2000,
pagine: 20 - 27
SICI:
8756-0437(200007/08)19:1<20:POCC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAPILLARY SEROUS CARCINOMA; FAMILIAL-OVARIAN-CANCER; HORMONE REPLACEMENT THERAPY; ORAL-CONTRACEPTIVE USE; BREAST-CANCER; FOLLOW-UP; SUSCEPTIBILITY GENE; PRIOR HYSTERECTOMY; MUTATION CARRIERS; DECISION-ANALYSIS;
Keywords:
ovarian neoplasms/epidemiology/genetics/prevention and control/surgery; ovariectomy; hysterectomy; genetic screening; genetic predisposition to disease; breast neoplasms/epidemiology/genetics; hereditary nonpolyposis colorectal neoplasms; genetic markers; BRCA1 genes; non-steroidal estrogens; prophylactic surgery;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Gotlieb, WH Tel Aviv Univ, Chaim Sheba Med Ctr, Div Gynecol Oncol, IL-52621 Tel Hashomer, Israel Tel Aviv Univ Tel Hashomer Israel IL-52621 Hashomer, Israel
Citazione:
W.H. Gotlieb et al., "Prophylactic oophorectomy: Clinical considerations", SEM SURG ON, 19(1), 2000, pp. 20-27

Abstract

Ovarian cancer usually remains clinically silent until it is far advanced,and is associated with significant morbidity and mortality. In view of themodest impact of adjuvant treatments on survival, much effort is devoted to early detection programs and prevention strategies. However, the usefulness of early detection programs remains to be established, with only one randomized study indicating improved median survival in screened individuals. At present, oral contraceptives and prophylactic oophorectomy are the only options for prevention of ovarian cancer. Indications for prophylactic oophorectomy either as a primary procedure, or secondary to abdominal surgery, will vary according to the estimated risk, and to the individual's perception of that risk. Genetic screening allows better identification of pre-symptomatic individuals who would benefit the most from prophylactic oophorectomy. Data concerning the benefit of prophylactic surgery, and the safety of established or innovative hormone replacement therapies in individuals at risk, are encouraging. Semin. Surg. Oncol. 19:20-27, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:54:51