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Titolo:
Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia
Autore:
Szeszko, PR; Bilder, RM; Lencz, T; Ashtari, M; Goldman, RS; Reiter, G; Wu, HW; Lieberman, JA;
Indirizzi:
Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat Res, Glen Oaks, NY 11004 USA Hillside Hosp Glen Oaks NY USA 11004 sychiat Res, Glen Oaks, NY 11004 USA Albert Einstein Coll Med, Dept Psychiat, Bronx, NY 10461 USA Albert Einstein Coll Med Bronx NY USA 10461 Psychiat, Bronx, NY 10461 USA Nathan S Kline Inst Psychiat Res, Ctr Adv Brain Imaging, Orangeburg, NY 10962 USA Nathan S Kline Inst Psychiat Res Orangeburg NY USA 10962 rg, NY 10962 USA N Shore Long Isl Jewish Hlth Syst, Dept Radiol, New Hyde Park, NY 11040 USA N Shore Long Isl Jewish Hlth Syst New Hyde Park NY USA 11040 NY 11040 USA Univ N Carolina, Dept Psychiat, Chapel Hill, NC 27599 USA Univ N CarolinaChapel Hill NC USA 27599 chiat, Chapel Hill, NC 27599 USA
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2-3, volume: 43, anno: 2000,
pagine: 97 - 108
SICI:
0920-9964(20000616)43:2-3<97:RACGVC>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; BRAIN MORPHOLOGY; PREFRONTAL CORTEX; TEMPORAL-LOBE; 1ST-EPISODE SCHIZOPHRENIA; STRUCTURAL ABNORMALITIES; MONOZYGOTIC TWINS; CEREBRAL-CORTEX; NORMAL CHILDREN; SEX-DIFFERENCES;
Keywords:
anterior cingulate gyrus volume; executive dysfunction; first-episode schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
70
Recensione:
Indirizzi per estratti:
Indirizzo: Szeszko, PR Hillside Hosp, N Shore Long Isl Jewish Hlth Syst, Dept Psychiat Res, 75-59263rd St, Glen Oaks, NY 11004 USA Hillside Hosp 75-59 263rd St Glen Oaks NY USA 11004 11004 USA
Citazione:
P.R. Szeszko et al., "Reduced anterior cingulate gyrus volume correlates with executive dysfunction in men with first-episode schizophrenia", SCHIZOPHR R, 43(2-3), 2000, pp. 97-108

Abstract

Although frontal lobe structural and functional abnormalities have been identified in schizophrenia, their relationship remains elusive. Because the frontal lobes are both structurally and functionally heterogeneous, it is possible that some measures of frontal lobe structure may not have accurately identified relevant frontal lobe subregions. The authors hypothesized that the volumes of two dorsal, 'archicortical' subregions (i.e. superior frontal gyrus and anterior cingulate gyrus), but not a ventral, 'paleocortical'subregion (i.e. orbital frontal region) would be significantly and selectively correlated with executive and motor dysfunction in patients with schizophrenia as previously reported for the anterior hippocampal region. Volumes of these frontal lobe subregions were measured from magnetic resonance images based on sulcal anatomy in 20 men and 15 women with first-episode schizophrenia. All patients completed a comprehensive neuropsychological test battery while clinically stabilized that encompassed six domains of functioning: attention, executive, motor, visuospatial, memory and language. Findings indicated that reduced anterior cingulate gyrus volume was significantlycorrelated with worse executive functioning in men; among women, there were no significant correlations. Among men, anterior cingulate gyrus volume was significantly more strongly correlated with executive functioning than with attention, visuospatial, memory, language and general intellectual functioning. Neither executive nor motor functioning was significantly more strongly correlated with the dorsal 'archicortical' volumes than with orbital frontal volume. These findings suggest a link between executive deficits and dysfunction of the dorsal 'archicortical' system and implicate sex differences in their relationship in first-episode schizophrenia. (C) 2000 Elsevier Science B.V. All rights reserved.

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Documento generato il 02/04/20 alle ore 22:24:05