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Titolo:
FOLLICULAR BASAL-CELL HYPERPLASIA OVERLYING DERMATOFIBROMA
Autore:
CHENG L; AMINI SB; ZAIM MT;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,INST PATHOL CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DERMATOL LAB CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT EPIDEMIOL & BIOSTAT CLEVELAND OH 44106 UNIV HOSP CLEVELAND CLEVELAND OH 44106
Titolo Testata:
The American journal of surgical pathology
fascicolo: 6, volume: 21, anno: 1997,
pagine: 711 - 718
SICI:
0147-5185(1997)21:6<711:FBHOD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HISTIOCYTOMA;
Keywords:
FOLLICULAR BASAL CELL HYPERPLASIA; DERMATOFIBROMA; HAIR FOLLICLE DIFFERENTIATION; SEBORRHEIC KERATOSIS; CLEAR CELL HYPERPLASIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
L. Cheng et al., "FOLLICULAR BASAL-CELL HYPERPLASIA OVERLYING DERMATOFIBROMA", The American journal of surgical pathology, 21(6), 1997, pp. 711-718

Abstract

Follicular basal cell hyperplasia (FBCH) overlying dermatofibroma represents aborted or impeded pilar differentiation. Historically, this hyperplasia has been misinterpreted as basal cell carcinoma. In a largeseries of dermatofibroma (258 cases), those that contained primitive or malformed follicular structures over the lesion (59 cases) were compared with those without such elements (199 cases). Statistical analysis of various clinicopathologic features showed that FBCH was significantly associated with younger age, trunk location, hypercellular dermatofibroma, loss of a Grenz zone, clear cell hyperplasia, and seborrheic keratosis-like change. There was an inverse correlation between epidermal atrophy, lichen simplex chronicus-like change, and lower extremity location with FBCH. Histologic features favoring a diagnosis of FBCH over basal cell carcinoma are the focal nature and superficial location of the lesion, lack of cytologic atypia and mitoses, recognizable components of hair follicle differentiation, focal condensation of mesenchymal cells around basal cell proliferation, and the association ofepidermal hyperplasia. Our findings suggest that FBCH, clear cell hyperplasia, and seborrheic keratosis-like change all represent an expression of follicular differentiation overlying dermatofibroma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 02:41:05