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Titolo:
INSULIN-LIKE-GROWTH-FACTOR-I INCREASES RENAL 1,25(OH)(2)D-3 BIOSYNTHESIS DURING LOW-P DIET IN ADULT-RATS
Autore:
WONG MS; SRIUSSADAPORN S; TEMBE VA; FAVUS MJ;
Indirizzi:
UNIV CHICAGO,SCH MED,DEPT MED,ENDOCRINOL SECT,5841 S MARYLAND AVE MC 5100 CHICAGO IL 60637 UNIV CHICAGO,SCH MED,DEPT MED,ENDOCRINOL SECT CHICAGO IL 60637 UNIV CHICAGO,SCH MED,DEPT MED,NEPHROL PROGRAM CHICAGO IL 60637
Titolo Testata:
American journal of physiology. Renal, fluid and electrolyte physiology
fascicolo: 6, volume: 41, anno: 1997,
pagine: 698 - 703
SICI:
0363-6127(1997)41:6<698:IIR1B>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHORUS RESTRICTION; PHOSPHATE DEPRIVATION; PARATHYROID-HORMONE; INTESTINAL CALCIUM; D METABOLISM; 1,25-DIHYDROXYVITAMIN-D3; AGE; ABSORPTION; EXPRESSION; RECEPTORS;
Keywords:
PROXIMAL TUBULE; 25-HYDROXYVITAMIN D-3-1-ALPHA-HYDROXYLASE; SERUM 1,25-DIHYDROXYVITAMIN D-3; CALCIUM; MINIOSMOTIC PUMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
M.S. Wong et al., "INSULIN-LIKE-GROWTH-FACTOR-I INCREASES RENAL 1,25(OH)(2)D-3 BIOSYNTHESIS DURING LOW-P DIET IN ADULT-RATS", American journal of physiology. Renal, fluid and electrolyte physiology, 41(6), 1997, pp. 698-703

Abstract

Dietary P restriction increases renal 1,25-dihydroxyvitamin D-3 [1,25(OH)(2)D-3] biosynthesis through stimulation of proximal tubule 25-hydroxyvitamin D-2-1 alpha-hydroxylase (1-OHase). Because insulin-like growth factor I (IGF-I) is required for 1-OHase stimulation by low-P diet (LPD) and because 1-OHase stimulation by low-Ca diet and parathyroidhormone is lost with aging, studies were undertaken to determine whether 1-OHase activity during LPD is impaired with age and whether IGF-Ican increase 1-OHase activity in adult rats. Five days of LPD increased in vitro 1-OHase activity in young(97.3 +/- 13.5 vs. 49.7 +/- 6.8 pg mg protein(-1).5 min(-1), P < 0.005) but not adult (42.3 +/- 5.37 vs. 41.2 +/- 8.9) rats. In LPD-fed adult rats, recombinant human IGF-I (rhIGF-I, 1.4 mg kg body wt(-1).day(-1)) for 72 h increased 1-OHase (65.2 +/- 5.88 vs. 95.1 +/- 7.26 pg mg protein(-1) 5 min(-1), P < 0.005). The results show that the rise in 1-OHase activity during LPD is lostin adult rats and that rhIGF-I can overcome the inhibition and stimulate renal 1-OHase activity to levels observed in young animals. The studies indicate that the age-related loss of 1-OHase activity is reversible.

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Documento generato il 18/09/20 alle ore 09:56:36