Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ASSOCIATION BETWEEN ALA54THR SUBSTITUTION OF THE FATTY-ACID-BINDING PROTEIN-2 GENE WITH INSULIN-RESISTANCE AND INTRAABDOMINAL FAT THICKNESSIN JAPANESE MEN
Autore:
YAMADA K; YUAN X; ISHIYAMA S; KOYAMA K; ICHIKAWA F; KOYANAGI A; KOYAMA W; NONAKA K;
Indirizzi:
KURUME UNIV,SCH MED,DEPT MED,DIV ENDOCRINOL & METAB,67 ASAHIMACHI KURUME FUKUOKA 830 JAPAN KUMAMOTO RED CROSS,HLTH CARE CTR KUMAMOTO JAPAN
Titolo Testata:
Diabetologia
fascicolo: 6, volume: 40, anno: 1997,
pagine: 706 - 710
SICI:
0012-186X(1997)40:6<706:ABASOT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIMA-INDIANS; DIABETES-MELLITUS; VISCERAL FAT; GLUCOSE; LINKAGE; OBESITY; METABOLISM; IMPAIRMENT; MODEL;
Keywords:
FATTY ACID-BINDING PROTEIN 2; INTESTINAL FATTY ACID BINDING PROTEIN; INSULIN RESISTANCE; VISCERAL FAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
K. Yamada et al., "ASSOCIATION BETWEEN ALA54THR SUBSTITUTION OF THE FATTY-ACID-BINDING PROTEIN-2 GENE WITH INSULIN-RESISTANCE AND INTRAABDOMINAL FAT THICKNESSIN JAPANESE MEN", Diabetologia, 40(6), 1997, pp. 706-710

Abstract

Alanine to threonine substitution at codon 54 of the fatty acid-binding protein 2 (FABP2) gene was recently shown to be associated with insulin resistance in Pima Indians. It has been hypothesized that the mutation may result in enhanced intestinal uptake of fatty acids, and thereby an impairment of insulin action. We analysed the association of the Ala54Thr substitution with insulin sensitivity and abdominal fat thickness in 395 Japanese men aged 50.5 +/- 8.8 years (mean +/- SD) witha body mass index of 24.4 +/- 3.0 kg/m(2). The frequency of the Thr54allele was 0.34. Although the polymorphism was not significantly associated with diabetes or impaired glucose tolerance, subjects homozygous for the Thr54 allele had higher basal insulin levels. Analysis by homeostasis model assessment showed an association between the amino acid substitution and greater insulin resistance, and slightly higher beta-cell function. Oral glucose tolerance tests performed in 392 subjects without fasting hyperglycaemia showed higher 2-h insulin concentrations in individuals homozygous for the Thr54 allele when compared with heterozygotes or homozygotes for the Ala54 allele. No significant association was obtained between the polymorphism of the FABP2 gene and body mass index. However, ultrasound measurements of abdominal fat thickness revealed a greater accumulation of intra-abdominal fat in subjects homozygous for the Thr54 allele, whereas subcutaneous fat thickness was not associated with the polymorphism. These observations suggest that the Ala54Thr substitution in the FABP2 gene is associated with insulin resistance in Japanese men, and that visceral fat accumulation might be involved in the impaired insulin action associated with the substitution.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 20:31:53