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Titolo:
GENETIC-STUDIES OF NEUROPEPTIDE-Y AND NEUROPEPTIDE-Y RECEPTORS Y1 ANDY5 REGIONS IN MORBID-OBESITY
Autore:
ROCHE C; BOUTIN P; DINA C; GYAPAY G; BASDEVANT A; HAGER J; GUYGRAND B; CLEMENT K; FROGUEL P;
Indirizzi:
INST PASTEUR,CNRS EP10,1 RUE CALMETTE,BP 245 F-59019 LILLE FRANCE CHU LILLE F-59037 LILLE FRANCE GENETHON EVRY FRANCE URA 1922 EVRY FRANCE HOP HOTEL DIEU,DEPT NUTR F-75181 PARIS FRANCE
Titolo Testata:
Diabetologia
fascicolo: 6, volume: 40, anno: 1997,
pagine: 671 - 675
SICI:
0012-186X(1997)40:6<671:GONANR>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN HOMOLOG; PEPTIDE YY; EXPRESSION; CLONING; SUBTYPE; LOCALIZATION; LINKAGE; BRAIN; RATS;
Keywords:
OBESITY; GENETIC; BODY MASS INDEX; NEUROPEPTIDE Y; NEUROPEPTIDE Y RECEPTORS; LEPTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C. Roche et al., "GENETIC-STUDIES OF NEUROPEPTIDE-Y AND NEUROPEPTIDE-Y RECEPTORS Y1 ANDY5 REGIONS IN MORBID-OBESITY", Diabetologia, 40(6), 1997, pp. 671-675

Abstract

Synthesis and release of neuropeptide Y (NPY) are both regulated by leptin binding to its hypothalamic receptor mediating some of the effects of leptin on food intake. Moreover, NPY administration is a powerful stimulant of feeding behaviour. Thus, we investigated the potential implication of NPY, NPY-Y1 and -Y5 subtype receptors [rNPY-Y1/-Y5] in the development of human obesity. Two complementary genetic approacheswere used: 1) linkage analyses between obesity and polymorphic markers located nearby NPY and rNPY-Y1/-Y5 genes (respectively on chromosomes 7p15.1 and 4q[31.3-32]) in 93 French Caucasian morbidly obese families; 2) single strand conformation polymorphism (SSCP) scanning of the coding region of the NPY and rNPY-Y1 genes performed in 50 unrelated obese patients ascertained on the basis of a body mass index of 27 kg/m(2) or more and a family history of obesity. No evidence of linkage between morbid obesity or obesity-related quantitative traits and NPY and rNPY-Y1/Y5 regions was found in this population. Moreover, SSCP scanning revealed no mutation in the coding region of NPY and rNPY-Y1 genes among obese subjects. These results suggest that NPY and NPY-Y1/Y5 receptors are unlikely to be implicated in the development of human morbid obesity, at least in the French Caucasian population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 07:16:35