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Titolo:
p51A (TAp63 gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation
Autore:
Katoh, I; Aisaki, K; Kurata, S; Ikawa, S; Ikawa, Y;
Indirizzi:
Tokyo Med & Dent Univ, Div Med Res, Dept Retroviral Regulat, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 Regulat, Tokyo 1138519, Japan Tokyo Med & Dent Univ, Human Gene Sci Ctr, Tokyo 1138510, Japan Tokyo Med & Dent Univ Tokyo Japan 1138510 Sci Ctr, Tokyo 1138510, Japan Tokyo Med & Dent Univ, Med Res Inst, Tokyo 1138510, Japan Tokyo Med & DentUniv Tokyo Japan 1138510 Res Inst, Tokyo 1138510, Japan Tohoku Univ, Inst Dev Aging & Canc, Dept Cell Biol, Sendai, Miyagi 9808575, Japan Tohoku Univ Sendai Miyagi Japan 9808575 ol, Sendai, Miyagi 9808575, Japan
Titolo Testata:
ONCOGENE
fascicolo: 27, volume: 19, anno: 2000,
pagine: 3126 - 3130
SICI:
0950-9232(20000622)19:27<3126:P(GAPH>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPERATURE-SENSITIVE MUTANT; KINASE C-ABL; MUTATIONAL ANALYSIS; IONIZING-RADIATION; APOPTOTIC RESPONSE; IN-VIVO; GENE; P63; PHOSPHORYLATION; PROLIFERATION;
Keywords:
p51; p63; p53; p21(wafI); Bax; DNA damage;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Ikawa, Y Tokyo Med & Dent Univ, Div Med Res, Dept Retroviral Regulat, Tokyo 1138519, Japan Tokyo Med & Dent Univ Tokyo Japan 1138519 Tokyo 1138519, Japan
Citazione:
I. Katoh et al., "p51A (TAp63 gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation", ONCOGENE, 19(27), 2000, pp. 3126-3130

Abstract

p51A, or TAp63 gamma, a translation product of gene p51, or p63, was identified as a homolog of p53 in its primary structure and transactivating function. p53 plays a decision-making role in inducing either cell cycle arrestor apoptosis in response to DNA damage, and thereby preserves genome integrity of living cells, To compare the biological activities between p51A andp53, cell lines with low-level, constitutive expression of each protein were obtained by cDNA transfection of mouse erythroleukemic cells. Productionof p51A with an apparent molecular mass of 57-kilodalton (kD) accompanied induction of p21(wafl) and appearance of hemoglobin-producing cells. After DNA-damaging treatment either with ultraviolet light (UV) irradiation or with actinomycin D, the p51A protein accumulated in time courses corresponding to those of wild-type p53, and caused an increase in the hemoglobin-positive cell count. In contrast, p53-accumulated cells underwent apoptosis without exhibiting the feature of erythroid differentiation, The mode of p21(wafl) and Bax-alpha upregulations varied between p51A- and p53-expressing cells and between the types of DNA damage. These results suggest the possibility that p51A induces differentiation under genotoxic circumstances. There may be cellular factors that control p51A protein stability and transactivating ability.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 19:19:38