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Titolo:
Alpha(1)-adrenoceptor-mediated excitation of substantia nigra pars reticulata neurons
Autore:
Berretta, N; Bernardi, G; Mercuri, NB;
Indirizzi:
Fdn S Lucia IRCCS, I-00179 Rome, Italy Fdn S Lucia IRCCS Rome Italy I-00179 S Lucia IRCCS, I-00179 Rome, Italy Univ Roma Tor Vergata, Neurol Clin, I-00173 Rome, Italy Univ Roma Tor Vergata Rome Italy I-00173 eurol Clin, I-00173 Rome, Italy
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 98, anno: 2000,
pagine: 599 - 604
SICI:
0306-4522(2000)98:3<599:AEOSNP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
BASAL GANGLIA; GABAERGIC NEURONS; LOCUS-COERULEUS; GUINEA-PIG; IN-VITRO; RAT; NORADRENALINE; RECEPTORS; DOPAMINE; CELLS;
Keywords:
noradrenaline; phenylephrine; basal ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mercuri, NB Fdn S Lucia IRCCS, Via Ardeatine 306, I-00179 Rome, Italy Fdn S Lucia IRCCS Via Ardeatine 306 Rome Italy I-00179 Italy
Citazione:
N. Berretta et al., "Alpha(1)-adrenoceptor-mediated excitation of substantia nigra pars reticulata neurons", NEUROSCIENC, 98(3), 2000, pp. 599-604

Abstract

The effect of noradrenaline was studied in principal neurons of the substantia nigra pars reticulata in rat brain slices using patch clamp recordings. Perfusion of noradrenaline or the alpha(1)-adrenoceptor agonist phenylephrine increased the spontaneous firing activity of reticulata cells. The alpha(1)-adrenoceptor antagonist prazosin counteracted the effects of noradrenaline. In contrast, the beta-adrenoceptor agonist isoproterenol did not affect the activity of reticulata cells and the beta-adrenoceptor antagonist pindolol did not prevent noradrenaline's effect. In whole-cell recordings, at -60 mV holding potential, noradrenaline caused a tetrodotoxin-resistant inward current with a time-course similar to the increase in firing activity. Analysis of the reversal potential of this current did not give homogeneous results. The net noradrenaline current could be associated with a conductance decrease or increase, or in some cases it did not reverse over a range from -120 to -30 mV. It is suggested that noradrenaline increases the excitability of substantia nigra reticulata cells through alpha(1)-adrenoceptors. Both a reduction and an increase in membrane conductance may mediate this effect. The increase in the tonic firing of principal reticulata cells caused by noradrenaline may have significant consequences in regulating the final output of the basal ganglia and consequently in motor-related behaviours. (C) 2000 IBRO. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 04:25:22