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Titolo:
Inhibitory transmission mediated by asynchronous transmitter release
Autore:
Lu, T; Trussell, LO;
Indirizzi:
Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 es Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ, Vollum Inst, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 m Inst, Portland, OR 97201 USA
Titolo Testata:
NEURON
fascicolo: 3, volume: 26, anno: 2000,
pagine: 683 - 694
SICI:
0896-6273(200006)26:3<683:ITMBAT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
FROG NEUROMUSCULAR JUNCTION; SUPERIOR OLIVARY NUCLEUS; PURKINJE-CELL SYNAPSE; SQUID GIANT SYNAPSE; HIPPOCAMPAL-NEURONS; DELAYED RELEASE; BRAIN-STEM; POSTTETANIC POTENTIATION; NEUROTRANSMITTER RELEASE; COINCIDENCE DETECTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Trussell, LO Oregon Hlth Sci Univ, Oregon Hearing Res Ctr, Portland, OR 97201 USA Oregon Hlth Sci Univ Portland OR USA 97201 and, OR 97201 USA
Citazione:
T. Lu e L.O. Trussell, "Inhibitory transmission mediated by asynchronous transmitter release", NEURON, 26(3), 2000, pp. 683-694

Abstract

At fast CNS synapses, the role of asynchronous release following initial synchronous release is poorly understood. We examined the contribution of asynchronous release to GABAergic transmission in the cochlear nucleus acrossa 40-fold range of electrical stimulus frequencies. Whereas quantal release was highly synchronized at low frequencies, it was largely continous and desynchronized at high frequencies. Despite the change in release mode, intense and steady inhibitory transmission was virtually maintained. Experimental analyses and modeling studies indicated that this "desynchronization" process was dependent on presynaptic Ca2+ accumulation, facilitation of vesicle release, and short-term depletion of available vesicles. Asynchronous release at high frequencies may help generate a smooth inhibitory "tone" by minimizing the consequences of random timing of presynaptic action potentials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:10:57