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Titolo:
Effects of glucose on scopolamine-induced learning deficits in rats performing the Morris water maze task
Autore:
Okaichi, Y; Okaichi, H;
Indirizzi:
Doshisha Univ, Dept Psychol, Kyoto 6028580, Japan Doshisha Univ Kyoto Japan 6028580 iv, Dept Psychol, Kyoto 6028580, Japan
Titolo Testata:
NEUROBIOLOGY OF LEARNING AND MEMORY
fascicolo: 1, volume: 74, anno: 2000,
pagine: 65 - 79
SICI:
1074-7427(200007)74:1<65:EOGOSL>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUS-ALTERNATION PERFORMANCE; HIPPOCAMPAL ACETYLCHOLINE-RELEASE; CHOLINERGIC RECEPTOR BLOCKADE; FREELY MOVING RATS; AGED RATS; MEMORY FACILITATION; TRAINING GLUCOSE; PLACE NAVIGATION; INDUCED AMNESIA; SWIMMING POOL;
Keywords:
glucose; spatial learning deficits; water maze; scopolamine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Okaichi, Y Doshisha Univ, Dept Psychol, Kyoto 6028580, Japan Doshisha Univ Kyoto Japan 6028580 ychol, Kyoto 6028580, Japan
Citazione:
Y. Okaichi e H. Okaichi, "Effects of glucose on scopolamine-induced learning deficits in rats performing the Morris water maze task", NEUROBIOL L, 74(1), 2000, pp. 65-79

Abstract

In order to assess the effects of glucose on drug-induced spatial learningdeficits, three experiments were conducted using the Morris water maze. Scopolamine and glucose were injected ip at various stages of training. Rats of Wistar strain served as subjects. In Experiment 1, scopolamine (0.4 mg/kg) and 10, 100, or 500 mg/kg of glucose were administered every day from the start of training, and the effect on acquisition was evaluated. In Experiment 2, scopolamine and 100 or 500 mg/kg of glucose were administered after6 days of training, and the effect on performance was assessed. In Experiment 3, scopolamine and 500 mg/kg of glucose were injected after 2 days of training, and the effect on the following trial was tested. In all experiments, scopolamine impaired acquisition/performance of the task. Glucose at 500 mg/kg showed a significant enhancing effect on acquisition regardless of scopolamine injection only when injected daily from the start of training (Experiment 1). Glucose injected after the performance has reached asymptote(Experiment 2) did not affect performance, and glucose in the middle of training showed a slight but insignificant enhancing effect (Experiment 3). These results may suggest that the effect of glucose changes as a function of the degree of learning of the spatial learning task. The possibility of task specificity of the glucose effect was also discussed in relation to thecholinergic systems and local cerebral glucose utilization. (C) 2000 Academic Press.

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Documento generato il 08/04/20 alle ore 23:51:50