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Titolo:
Increased excretions of beta(2)-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis
Autore:
Tsai, CY; Wu, TH; Yu, CL; Lu, JY; Tsai, YY;
Indirizzi:
Natl Yang Ming Univ, Taichung Vet Gen Hosp, Sect Allergy Immunol & Rheumatol, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 atol, Dept Med, Taipei 112, Taiwan Natl Yang Ming Univ, Taichung Vet Gen Hosp, Nephrol Sect, Dept Med, Taipei112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 Sect, Dept Med, Taipei112, Taiwan Natl Taiwan Univ Hosp, Dept Med, Taipei, Taiwan Natl Taiwan Univ Hosp Taipei Taiwan Univ Hosp, Dept Med, Taipei, Taiwan
Titolo Testata:
NEPHRON
fascicolo: 3, volume: 85, anno: 2000,
pagine: 207 - 214
SICI:
0028-2766(200007)85:3<207:IEOBIA>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR NECROSIS FACTOR; ERYTHEMATOSUS SLE; PROTEIN; RECEPTORS; BETA2-MICROGLOBULIN; GLOMERULONEPHRITIS; CLASSIFICATION; INTERLEUKIN-8; NEUTROPHILS; COMPLEMENT;
Keywords:
interleukin 6; interleukin 8; lupus nephritis; beta(2)-microglobulin; renal tubular function; Tamm-Horsfall glycoprotein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, CY Natl Yang Ming Univ, Taichung Vet Gen Hosp, Sect Allergy Immunol & Rheumatol, Dept Med, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan Natl Yang Ming Univ 201 Sec 2,Shih Pai Rd Taipei Taiwan 112 iwan
Citazione:
C.Y. Tsai et al., "Increased excretions of beta(2)-microglobulin, IL-6, and IL-8 and decreased excretion of Tamm-Horsfall glycoprotein in urine of patients with active lupus nephritis", NEPHRON, 85(3), 2000, pp. 207-214

Abstract

Tubulointerstitial nephritis is a less frequently recognized but importantcomplication of systemic lupus erythematosus. We have investigated the cytokine beta(2)-microglobulin (beta(2)M) and Tamm-Horsfall glycoprotein (THG)excretions in the urine of systemic lupus erythematosus patients to identify indices for evaluation of tubulointerstitial inflammation in lupus nephritis (LN). Daily urine was collected from 15 patients with active LN, from 12 patients with inactive LN, and from 17 normal subjects. The amounts of soluble interleukin (IL) 2 receptor, IL-6, IL-8, beta(2)M, and THG in urine were measured. beta(2)M and THG were regarded as indicators of proximal anddistal renal tubule function, respectively. The urinary excretions of IL-6and IL-8 were significantly higher in patients with active LN than in those with inactive LN and in normal individuals. The excretion of soluble IL-2receptor in all three groups of subjects was not significantly different. On the other hand, the excretion of beta(2)M in patients with LN was significantly higher than that in normal individuals. The excretion of beta(2)M in patients with active or inactive LN was not significantly different. The THG excretion was lower in patients with active LN and tubulointerstitial inflammation as compared with patients with inactive LN or normal individuals. Six patients underwent pulse cyclophosphamide therapy during the course of experiments. Five of them showed a decrease in IL-8 and IL-6 excretions in urine after the treatment. The excretions of PPM and THG in urine, in addition to IL-6 and IL-8, can reflect the renal inflammatory activity in patients with lupus tubulointerstitial nephritis as well as in those having lupus glomerulonephritis. Copyright (C) 2000 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 20:04:57