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Titolo:
Mutation of a glutamate receptor motif reveals its role in gating and delta 2 receptor channel properties
Autore:
Kohda, K; Wang, Y; Yuzaki, M;
Indirizzi:
St Jude Childrens Res Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA St Jude Childrens Res Hosp Memphis TN USA 38105 ol, Memphis, TN 38105 USA
Titolo Testata:
NATURE NEUROSCIENCE
fascicolo: 4, volume: 3, anno: 2000,
pagine: 315 - 322
SICI:
1097-6256(200004)3:4<315:MOAGRM>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM DEPRESSION; RAT HIPPOCAMPAL-NEURONS; METHYL-D-ASPARTATE; PURKINJE-CELLS; AMPA RECEPTORS; ACTIVATION KINETICS; CA2+ PERMEABILITY; NMDA RECEPTORS; BINDING-SITES; SUBUNIT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Yuzaki, M St Jude Childrens Res Hosp, Dept Dev Neurobiol, 332 N LauderdaleSt, Memphis, TN 38105 USA St Jude Childrens Res Hosp 332 N Lauderdale St Memphis TN USA 38105
Citazione:
K. Kohda et al., "Mutation of a glutamate receptor motif reveals its role in gating and delta 2 receptor channel properties", NAT NEUROSC, 3(4), 2000, pp. 315-322

Abstract

Despite its importance in the cerebellum, the functions of the orphan glutamate receptor delta 2 are unknown. We examined a mutant delta 2 receptor channel in lurcher mice that was constitutively active in the absence of ligand. Because this mutation was within a highly conserved motif (YTANLAAF), we tested its effect on several glutamate receptors. Mutant delta 2 receptors showed distinct channel properties, including double rectification of the current-voltage relationship, sensitivity to a polyamine antagonist and moderate Ca2+ permeability, whereas other constitutively active mutant glutamate channels resembled wildtype channels in these respects. Moreover, the kinetics of ligand-activated currents were strikingly altered. We conclude that the delta 2 receptor has a functional ion channel pore similar to thatof glutamate receptors. The motif may have a role in the channel gating ofglutamate receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 23:37:43