Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Endothelium-dependent vasodilatation in patients with familial amyloidoticpolyneuropathy
Autore:
Obayashi, K; Ando, Y; Nakamura, M; Terazaki, H; Yamashita, T; Tashima, K; Suga, M; Uchino, M; Ando, M;
Indirizzi:
Kumamoto Univ, Sch Med, Dept Lab Med, Kumamoto 8600811, Japan Kumamoto Univ Kumamoto Japan 8600811 pt Lab Med, Kumamoto 8600811, Japan Kumamoto Univ, Sch Med, Dept Neurol, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 h Med, Dept Neurol, Kumamoto 860, Japan Kumamoto Univ, Sch Med, Dept Internal Med 1, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ept Internal Med 1, Kumamoto 860, Japan
Titolo Testata:
MUSCLE & NERVE
fascicolo: 7, volume: 23, anno: 2000,
pagine: 1084 - 1088
SICI:
0148-639X(200007)23:7<1084:EVIPWF>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMENOPAUSAL ESTROGEN THERAPY; HEALTHY-YOUNG ADULTS; CORONARY-ARTERIES; JAPANESE TYPE; PRE-ALBUMIN; FOLLOW-UP; FLOW; ATHEROSCLEROSIS; DISEASE; HUMANS;
Keywords:
amyloid deposition; endothelium-dependent vasodilatation; FAP; peripheral arteries; ultrasonography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Ando, Y Kumamoto Univ, Sch Med, Dept Lab Med, 1-1-1 Honjo, Kumamoto 8600811, Japan Kumamoto Univ 1-1-1 Honjo Kumamoto Japan 8600811 o 8600811, Japan
Citazione:
K. Obayashi et al., "Endothelium-dependent vasodilatation in patients with familial amyloidoticpolyneuropathy", MUSCLE NERV, 23(7), 2000, pp. 1084-1088

Abstract

We examined endothelium-dependent vasodilatation in 15 familial amyloidotic polyneuropathy (FAP) amyloidogenic transthyretin (ATTR) Valine30Methionine (Val30Met) patients and 12 healthy volunteers. Using ultrasonography, we measured the radial artery diameters under both baseline and hyperemic conditions. Endothelium-dependent vasodilatation was expressed as a percent increase in the diameters of the radial artery after induced hyperemia. Endothelium-dependent vasodilatation tended to decrease in the patients, comparedwith healthy volunteers. Responses were not elicited at all in patients with disease of more than 9 years' duration. Linear negative correlation was observed between endothelium-dependent vasodilatation and disease duration (P < 0.01). Correlation between endothelium-dependent vasodilatation and degree of autonomic dysfunction was significant (P = 0.0524) and for age was close to significance (P = 0.051). These results suggest that the peripheral vasomotor dysfunction in FAP patients may predominantly depend on the amount of amyloid deposition around the vessels through the course of illness. (C) 2000 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 07:10:38