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Titolo:
Evaluation of cerebrospinal anticardiolipin antibodies in lupus patients with neuropsychiatric manifestations
Autore:
Lai, NS; Lan, JL;
Indirizzi:
ChiaYi Vet Hosp, Dept Med, Sect Allergy Immunol & Rheumatol, Chiayi, Taiwan ChiaYi Vet Hosp Chiayi Taiwan lergy Immunol & Rheumatol, Chiayi, Taiwan Taichung Vet Gen Hosp, Dept Med, Sect Allergy Immunol & Rheumatol, Chiati,Taiwan Taichung Vet Gen Hosp Chiati Taiwan Immunol & Rheumatol, Chiati,Taiwan
Titolo Testata:
LUPUS
fascicolo: 5, volume: 9, anno: 2000,
pagine: 353 - 357
SICI:
0961-2033(2000)9:5<353:EOCAAI>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPHOSPHOLIPID ANTIBODIES; CIRCULATING LUPUS; ERYTHEMATOSUS; DISEASE; CLASSIFICATION; ANTICOAGULANT; INVOLVEMENT; DISORDERS; PROGNOSIS; CRITERIA;
Keywords:
systemic lupus erythematosus (SLE); anticardiolipin antibody (aCL); cerebrospinal fluid (CSF); neuropsychiatric manifestation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Lai, NS ChiaYi Vet Hosp, Dept Med, Sect Allergy Immunol & Rheumatol, Chiayi, Taiwan ChiaYi Vet Hosp Chiayi Taiwan munol & Rheumatol, Chiayi, Taiwan
Citazione:
N.S. Lai e J.L. Lan, "Evaluation of cerebrospinal anticardiolipin antibodies in lupus patients with neuropsychiatric manifestations", LUPUS, 9(5), 2000, pp. 353-357

Abstract

To evaluate the role of cerebrospinal fluid (CSF) anticardiolipin antibody(aCL) in lupus patients with neuropsychiatric manifestations, paired measurements of aCL, in the serum and CSF, were performed using the ELISA methodin lupus patients (n = 31) and controls with other medical diseases (n = 8). High titers of CSF IgG-aCL were detected in cerebral lupus patients withlupus headache, acute psychosis, cognitive impairment, high cortical dysfunction, and altered consciousness. Intrathecal synthesis, rather than the diffusion of IgG-aCL from serum to compartment of the central nervous system, occurred in these NPLE patients. The binding of aCL to brain components might play a role in the development of neuropsychiatric manifestations in cerebral lupus patients.

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Documento generato il 18/01/20 alle ore 13:23:09