Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Leukotoxin, 9,10-epoxy-12-octadecenoate, causes pulmonary vasodilation by stimulation of vascular eNOS and iNOS
Autore:
Nakanishi, M; Ishizaki, T; Demura, Y; Okamura, S; Ameshima, S; Sasaki, F; Matsukawa, S; Miyamori, I;
Indirizzi:
Fukui Med Univ, Dept Internal Med 3, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 Internal Med 3, Fukui 9101193, Japan Fukui Med Univ, Cent Res Lab, Fukui 9101193, Japan Fukui Med Univ Fukui Japan 9101193 v, Cent Res Lab, Fukui 9101193, Japan
Titolo Testata:
LUNG
fascicolo: 3, volume: 178, anno: 2000,
pagine: 137 - 148
SICI:
0341-2040(200005/06)178:3<137:L9CPVB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; NITRIC-OXIDE SYNTHASE; ARTERY SMOOTH-MUSCLE; RELAXING FACTOR; LUNG; NEUTROPHILS; RATS;
Keywords:
leukotoxin; rat pulmonary artery; human pulmonary artery smooth muscle cell (HPASMC); NOS inhibitor; cyclicGMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Nakanishi, M Fukui Med Univ, Dept Internal Med, Fukui 9101193, Japan FukuiMed Univ Fukui Japan 9101193 ed, Fukui 9101193, Japan
Citazione:
M. Nakanishi et al., "Leukotoxin, 9,10-epoxy-12-octadecenoate, causes pulmonary vasodilation by stimulation of vascular eNOS and iNOS", LUNG, 178(3), 2000, pp. 137-148

Abstract

We have previously reported that leukotoxin, 9,10-epoxy-12-octadecenoate (Lx) dilates rat pulmonary arteries by means of nitric oxide synthase (NOS) activation. In this study, we investigated if Lx stimulates constitutive and/or inducible NOS. We studied the effect of the NOS inhibitors, N-G-monomethyl-L-arginine and aminoguanidine, as well as endothelium denudation on Lx-induced rat pulmonary arterial dilation and that of aminoguanidine on Lx-induced endothelium denuded lipopolysaccharide (LPS)-treated rat pulmonary arterial dilation and tissue cGMP content. Furthermore, we assessed the effect of aminoguanidine, an inducible NOS (iNOS) inhibitor, on the cGMP content increase induced by Lx in LPS-treated human pulmonary artery smooth muscle cells (HPASMC). The NOS inhibitors and endothelium denudation significantly attenuated Lx-induced vasodilation. Aminoguanidine also significantly attenuated Lx-induced vasodilation in LPS-treated rat denuded pulmonary arteries, and attenuated Lx-induced cGMP content increase in denuded pulmonary arterial rings from LPS-treated rats and in LPS-treated HPASMC. These results suggest that Lx causes pulmonary vasodilation by stimulation of vascular endothelial NOS (eNOS) and iNOS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:06:10