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Titolo:
Articular cartilage is more susceptible to blood induced damage at young than at old age
Autore:
Roosendaal, G; Tekoppele, JM; Vianen, ME; van den Berg, HM; Lafeber, FPJG; Bijlsma, JWJ;
Indirizzi:
Univ Utrecht, Med Ctr, Div Internal Med, Van Creveld Clin, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Rheumatol & Clin Immunol, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands TNO, Div Vasc & Connect Tissue Res, Prevent & Hlth, Leiden, Netherlands TNO Leiden Netherlands Tissue Res, Prevent & Hlth, Leiden, Netherlands
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 7, volume: 27, anno: 2000,
pagine: 1740 - 1744
SICI:
0315-162X(200007)27:7<1740:ACIMST>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEMOPHILIA-A; INDUCED JOINT DAMAGE; HUMAN IN-VITRO; OSTEOARTHRITIC CARTILAGE; ARTHROPATHY; PROPHYLAXIS; ARTHRITIS; CULTURE;
Keywords:
cartilage; canine; hemophilia; proteoglycan; blood; arthropathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Roosendaal, G Univ Utrecht, Med Ctr, Div Internal Med, Van Creveld Clin, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA lands
Citazione:
G. Roosendaal et al., "Articular cartilage is more susceptible to blood induced damage at young than at old age", J RHEUMATOL, 27(7), 2000, pp. 1740-1744

Abstract

Objective. It has been shown that cartilage is damaged upon intraarticularhemorrhage. We investigated differences in the susceptibility of cartilagefrom young adult and old animals to blood induced joint damage in a caninein vivo model. Methods. Right knees of 6 young adult beagles (aged 2.2 +/- 0.1 yrs) and 6old beagles (7.4 +/- 0.3 yrs) were intraarticularly injected twice in 4 days with autologous blood. Dogs were killed 4 or 16 days after the first injection and cartilage matrix proteoglycan content and synthesis and collagendamage were determined. Results. Shortly after blood injection (Day 4), proteoglycan synthesis wasinhibited and the proteoglycan content of the cartilage was decreased in both groups. However, the degree of the inhibition of proteoglycan synthesiswas significantly greater in young adult animals than in old animals. On Day 16 proteoglycan synthesis was increased in both young adult and old cartilage, but more elevated in old cartilage. The proteoglycan content remained decreased in both young adult and old cartilage, but significantly moresoin young adult cartilage than in old cartilage. Conclusion. Results suggest that intraarticular bleeding influences cartilage metabolism and repair, and that the cartilage of young adult animals ismore susceptible to these influences than cartilage of old animals. Differences in the aging of chondrocytes and age related changes in matrix integrity may be involved. Prevention and appropriate treatment of joint bleedingis indicated and this is especially relevant for young adult cartilage.

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Documento generato il 21/09/20 alle ore 06:17:16