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Titolo:
Patterns of drug use in rheumatoid arthritis
Autore:
Berard, A; Solomon, DH; Avorn, J;
Indirizzi:
Brigham & Womens Hosp, Div Pharmacoepidemiol & Pharmacoecon, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 rmacoecon, Boston, MA 02115 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF RHEUMATOLOGY
fascicolo: 7, volume: 27, anno: 2000,
pagine: 1648 - 1655
SICI:
0315-162X(200007)27:7<1648:PODUIR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; MEDICAID DATA; PRESCRIPTION; THERAPY; AGENTS; RHEUMATOLOGISTS; PREDNISONE; ALBERTA; DISEASE; TRENDS;
Keywords:
rheumatoid arthritis; DMARD; corticosteroids; patterns of use; NSAID; pharmacoepidemiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Avorn, J Brigham & Womens Hosp, Div Pharmacoepidemiol & Pharmacoecon, 211 Longwood Ave, Boston, MA 02115 USA Brigham & Womens Hosp 211 Longwood Ave Boston MA USA 02115 15 USA
Citazione:
A. Berard et al., "Patterns of drug use in rheumatoid arthritis", J RHEUMATOL, 27(7), 2000, pp. 1648-1655

Abstract

Objective. Treatment strategies for rheumatoid arthritis (RA) are rapidly evolving, but few data exist on current prescribing patterns in distinct populations of patients and physicians. We described patterns of drug use forRA in a large population including use of nonsteroidal antiinflammatory drugs (NSAID), disease modifying antirheumatic drugs (DMARD), and corticosteroids. Methods. We identified a cohort of 10,262 New Jersey Medicaid/Medicore/PAAD (Pharmacy Assistance for the Aged and the Disabled) beneficiaries with atleast one episode of cart: for RA between January 1, 1992, and January 1, 1995, and at least one episode of carl after December 31, 1995. All patients were present for the entire study period and thus constituted a closed cohort. All filled prescriptions, hospitalizations, nursing home care, and physician visits during 1995 were analyzed. Results. The cohort was 67 years old on average, 82% female, and 63% white; 63% were enrolled in Medicaid and 9% were in a nursing home at the beginning of followup. During the study year, 68% of patients filled at least oneprescription for any of the drug groups studied. The most frequently prescribed medication was an NSAID (57%), followed by corticosteroids (23%) and DMARD (13%). Thirty-nine percent of patients used only NSAID, 2% only DMARD, and 6% only corticosteroid. Patients taking NSAID used them on average for 3 months during the study year, corticosteroids for 4 months, and DMARD for over 7 months. During the study year, one-third of DMARD users stopped all DMARD therapy. One-third of prednisone users were taking doses higher than 10 mg/day. Conclusion. While our RA cohort was older than would be expected, they represent a typical Medicare and Medicaid or PAAD population. In this cohort of patients with a diagnosis of RA cared for by either general practitionersor rheumatologists, NSAID were the most commonly prescribed medication, with substantially lower rates of use for DMARD and corticosteroids. Drug discontinuation and medication switching were common.

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Documento generato il 26/01/20 alle ore 22:17:29