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Titolo:
A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers
Autore:
Jonsson, EG; Norton, N; Gustavsson, JF; Oreland, L; Owen, MJ; Sedvall, GC;
Indirizzi:
Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ct, SE-17176 Stockholm, Sweden Univ Wales Coll Med, Dept Med Psychol, Cardiff CF4 4XN, S Glam, Wales UnivWales Coll Med Cardiff S Glam Wales CF4 4XN f CF4 4XN, S Glam, Wales Univ Skovde, Dept Hlth Sci, Skovde, Sweden Univ Skovde Skovde SwedenUniv Skovde, Dept Hlth Sci, Skovde, Sweden Univ Uppsala, Dept Neurosci, Pharmacol Sect, Uppsala, Sweden Univ UppsalaUppsala Sweden t Neurosci, Pharmacol Sect, Uppsala, Sweden
Titolo Testata:
JOURNAL OF PSYCHIATRIC RESEARCH
fascicolo: 3, volume: 34, anno: 2000,
pagine: 239 - 244
SICI:
0022-3956(200005/06)34:3<239:APPITM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBROSPINAL-FLUID; A GENE; FEMALE VOLUNTEERS; NORRIE DISEASE; X-CHROMOSOME; SMOKERS; LOCALIZATION; INDIVIDUALS; INHIBITION; AGE;
Keywords:
monoamine oxidase A gene; monoamine metabolites (HVA; 5-HIAA; MHPG); cerebrospinal fluid;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsson, EG Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
E.G. Jonsson et al., "A promoter polymorphism in the monoamine oxidase A gene and its relationships to monoamine metabolite concentrations in CSF of healthy volunteers", J PSYCH RES, 34(3), 2000, pp. 239-244

Abstract

Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid(CSF) have been used extensively as indirect estimates of monoamine turnover in the brain. We investigated possible relationships between a putative functional promoter polymorphism in the monoamine oxidase A (MAOA) gene andCSF concentrations of homovanillic acid (HVA). 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglycol (MHPG) in healthy volunteers (n = 88). Among women (n = 37), those carrying at least one copy of the alleles associated with more efficient transcription displayed higher concentrations of HVA (p = 0.01) and 5-HIAA (p = 0.01). In men (n = 51), however, there was a tendency in the opposite direction. The results suggest that MAOA genotypes may participate differentially in the regulation of dopamine and serotonin turnover rates under presumed steady state in the central nervous system. The results should be interpreted with caution until replicated because of the limited sample size. (C) 2000 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 15:59:15