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Titolo:
Lactulose-mannitol intestinal permeability test in children with diarrhea caused by rotavirus and Cryptosporidium
Autore:
Zhang, Y; Lee, B; Thompson, M; Glass, R; Lee, RC; Figueroa, D; Gilman, R; Taylor, D; Stephenson, C;
Indirizzi:
Univ Washington, Dept Family Med, Res Sect, DTM&H, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 s Sect, DTM&H, Seattle, WA 98195 USA Ctr Dis Control & Prevent, Atlanta, GA USA Ctr Dis Control & Prevent Atlanta GA USA trol & Prevent, Atlanta, GA USA Asociac Benefica PRISMA, Lima, Peru Asociac Benefica PRISMA Lima PeruAsociac Benefica PRISMA, Lima, Peru Inst Salud Ninos, Lima, Peru Inst Salud Ninos Lima PeruInst Salud Ninos, Lima, Peru Walter Reed Army Med Ctr, Walter Reed Army Inst Res, Dept Enter Infect, Washington, DC 20307 USA Walter Reed Army Med Ctr Washington DC USA 20307 Washington, DC 20307 USA Univ Calif Davis, Dept Nutr Sci, Davis, CA 95616 USA Univ Calif Davis Davis CA USA 95616 s, Dept Nutr Sci, Davis, CA 95616 USA
Titolo Testata:
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
fascicolo: 1, volume: 31, anno: 2000,
pagine: 16 - 21
SICI:
0277-2116(200007)31:1<16:LIPTIC>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTOMATED ENZYMATIC ASSAYS; PARVUM INFECTION; ZINC SUPPLEMENTATION; PERUVIAN CHILDREN; RURAL BANGLADESH; MALNUTRITION; GASTROENTERITIS; ASSOCIATION; ABSORPTION; BACTERIAL;
Keywords:
Cryptosporidium; diarrhea; intestinal permeability; lactulose; mannitol; rotavirus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Thompson, M Univ Washington, Dept Family Med, Res Sect, DTM&H, Box 354696,Seattle, WA98195 USA Univ Washington Box 354696 Seattle WA USA 98195 e, WA98195 USA
Citazione:
Y. Zhang et al., "Lactulose-mannitol intestinal permeability test in children with diarrhea caused by rotavirus and Cryptosporidium", J PED GASTR, 31(1), 2000, pp. 16-21

Abstract

Background: The relationship between intestinal permeability and acute secretory diarrheal syndromes caused by rotavirus and Cryptosporidium parvum in infants less than 36 months of age was studied using the lactulose-mannitol excretion assay. Methods: An oral solution containing 0.4 g/kg lactulose and 0.1 g/kg mannitol was administered to 15 infants with rotavirus. 7 with Cryptosporidium infection and a control group of 7 with secretory diarrhea admitted to the Oral Rehydration Unit of the National Children's Hospital in Lima, Peru. Urinary sugar excretion was measured using an enzymatic spectrophotometric method. The ratio of urinary excretion of lactulose to mannitol was used to measure intestinal mucosal permeability, with higher ratios indicative of increased intestinal permeability. Infants in all three groups were retested 20 days after the initial test. Results: The (mean +/- SE) lactulose:mannitol (L:M) excretion ratios during the acute phase (day 1) of diarrhea in infants with rotavirus or Cryptosporidium and control infants were 0.67 +/- 0.1. 0.76 +/- 0.16. and 0.26 +/- 0.04, respectively. In the convalescent phase (day 20) the ratios were 0.19+/- 0.02, 0.28 +/- 0.05, and 0.29 +/- 0.07, respectively. Significant reductions in L:hl ratios were noted in rotavirus patients between days 1 and 20 (paired t-test; P < 0.01), Cryptosporidium patients between days 1 and 20(paired t-test; P < 0.05), and between control subjects on day 1 and rotavirus patients on day 1 and Cryptosporidium patients on day 1 (unpaired t-tests; P < 0.05 for both). There were no significant differences in control subjects between days 1 and 20, control subjects and rotavirus patients on day 20, or control subjects and Cryptosporidium patients on day 20. Conclusions: The results indicate that increased intestinal permeability caused by rotavirus or cryptosporidium infections in Peruvian infants less than 36 months of age is a significant but reversible phenomenon. The temporal relationship observed in the current study and the contribution of such alterations in intestinal mucosal integrity to the burden of diarrheal disease and the development of malnutrition in developing countries is discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 00:23:27