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Titolo:
Adeno-associated virus vectors: activity and applications in the CNS
Autore:
Peel, AL; Klein, RL;
Indirizzi:
Buck Ctr Res Aging, Novato, CA 94948 USA Buck Ctr Res Aging Novato CA USA94948 tr Res Aging, Novato, CA 94948 USA Univ Florida, Dept Pharmacol, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 harmacol, Gainesville, FL 32610 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE METHODS
fascicolo: 2, volume: 98, anno: 2000,
pagine: 95 - 104
SICI:
0165-0270(20000601)98:2<95:AVVAAA>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
GREEN FLUORESCENT PROTEIN; SOMATIC GENE-TRANSFER; NERVE GROWTH-FACTOR; ADENOASSOCIATED VIRUS; NEUROTROPHIC FACTOR; PARKINSONS-DISEASE; AAV VECTOR; RAT MODEL; ALZHEIMERS-DISEASE; TRANSGENIC MICE;
Keywords:
adeno-associated virus (AAV); disease-modeling; gene therapy; gene transfer; neurodegenerative disease; neurotrophic factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
66
Recensione:
Indirizzi per estratti:
Indirizzo: Peel, AL Buck Ctr Res Aging, POB 638,8001 Redwood Blvd, Novato, CA 94948 USA Buck Ctr Res Aging POB 638,8001 Redwood Blvd Novato CA USA 94948
Citazione:
A.L. Peel e R.L. Klein, "Adeno-associated virus vectors: activity and applications in the CNS", J NEUROSC M, 98(2), 2000, pp. 95-104

Abstract

Transgenic strategies are useful for functional studies and they may also lead to novel therapies. Controlling transgene expression in defined cell populations over time is increasingly important for both functional and genetherapy experiments. The adeno-associated virus (AAV) vector may provide sufficient spatio-temporal control of gene expression for these purposes. This paper reviews in vivo somatic gene transfer methodology using AAV. Advantageous features of this system include neuronal gene expression that is: (1) efficient; (2) long-lived; and (3) non-toxic. Thus, AAV-mediated gene transfer is a good method for functional genomic research. From characterizing vector activity in the brain using different combinations of promoters and transgenes in the mid to late 1990s, researchers continue to discover novel uses of AAV for both basic and clinical neuroscience. (C) 2000 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/05/20 alle ore 09:56:06