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Titolo:
Periodicity and firing rate as candidate neural codes for the frequency ofvibrotactile stimuli
Autore:
Salinas, E; Hernandez, A; Zainos, A; Romo, R;
Indirizzi:
Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510, DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 y 04510, DF, Mexico
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 20, anno: 2000,
pagine: 5503 - 5515
SICI:
0270-6474(20000715)20:14<5503:PAFRAC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOMATIC SENSORY CORTEX; PRIMARY SOMATOSENSORY CORTEX; MONKEYS MACACA-MULATTA; NEURONAL-ACTIVITY; PSYCHOPHYSICAL MEASUREMENTS; CORTICAL-NEURONS; VISUAL-CORTEX; SINGLE UNITS; MOTOR CORTEX; INFORMATION;
Keywords:
awake monkeys; primary somatosensory cortex; secondary somatosensory cortex; neural coding; flutter; discrimination; periodicity; mutual information;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Romo, R Univ Nacl Autonoma Mexico, Inst Fisiol Celular, Mexico City 04510,DF, Mexico Univ Nacl Autonoma Mexico Mexico City DF Mexico 04510 DF, Mexico
Citazione:
E. Salinas et al., "Periodicity and firing rate as candidate neural codes for the frequency ofvibrotactile stimuli", J NEUROSC, 20(14), 2000, pp. 5503-5515

Abstract

The flutter sensation is felt when mechanical vibrations between 5 and 50 Hz are applied to the skin. Neurons with rapidly adapting properties in thesomatosensory system of primates are driven very effectively by periodic flutter stimuli; their evoked spike trains typically have a periodic structure with highly regular time differences between spikes. A long-standing conjecture is that, such periodic structure may underlie a subject's capacity to discriminate the frequencies of periodic vibrotactile stimuli and that, in primary somatosensory areas, stimulus frequency is encoded by the regular time intervals between evoked spikes, not by the mean rate at which theseare fired. We examined this hypothesis by analyzing extracellular recordings from primary (S1) and secondary (S2) somatosensory cortices of awake monkeys performing a frequency discrimination task. We quantified stimulus-driven modulations in firing rate and in spike train periodicity, seeking to determine their relevance for frequency discrimination. We found that periodicity was extremely high in S1 but almost absent in S2. We also found that periodicity was enhanced when the stimuli were relevant for behavior. However, periodicity did not covary with psychophysical performance in single trials. On the other hand, rate modulations were similar in both areas, and with periodic and aperiodic stimuli, they were enhanced when stimuli were important for behavior, and were significantly correlated with psychophysicalperformance in single trials. Thus, the exquisitely timed, stimulus-drivenspikes of primary somatosensory neurons may or may not contribute to the neural code for flutter frequency, but firing rate seems to be an important component of it.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 09:08:24