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Titolo:
Combined lesions of hippocampus and subiculum do not produce deficits in anonspatial social olfactory memory task
Autore:
Burton, S; Murphy, D; Qureshi, U; Sutton, P; OKeefe, J;
Indirizzi:
Univ Coll London, Dept Anat & Dev Biol, London WC1E 6BT, England Univ CollLondon London England WC1E 6BT Biol, London WC1E 6BT, England
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 20, anno: 2000,
pagine: 5468 - 5475
SICI:
0270-6474(20000715)20:14<5468:CLOHAS>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CINGULUM BUNDLE; RATS; TESTS; DIET;
Keywords:
memory; social transmission; food preference; hippocampus; subiculum; amygdala; nonspatial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: O'Keefe, J Univ Coll London, Dept Anat & Dev Biol, Gower St, London WC1E 6BT, England Univ Coll London Gower St London England WC1E 6BT 6BT, England
Citazione:
S. Burton et al., "Combined lesions of hippocampus and subiculum do not produce deficits in anonspatial social olfactory memory task", J NEUROSC, 20(14), 2000, pp. 5468-5475

Abstract

Rats transmit information to each other about which foods are safe to eat. If a rat smells a food odor on the breath of another rat, it is subsequently more likely to eat that food than an alternative. Work by Galef et al. (1988) has shown that the observer rat forms an association between two olfactory stimuli on the breath of the demonstrator rat that has eaten the food, the food odor and carbon disulphide, which is normally present in the ratbreath. Bunsey and Eichenbaum (1995) claimed that the hippocampus/subicular region is required for the long-term retention of this nonspatial form ofassociative memory on the basis that combined lesions of the hippocampus and subiculum produced a deficit, but lesions of either structure alone did not. We report here a failure to repeat this finding. Rats with either combined lesions of the hippocampus and subiculum or with amygdala lesions weretested on their ability to remember this association either immediately (testing short-term memory) or after a 24 hr delay (testing long-term memory). Neither lesion group exhibited significant memory deficits on this nonspatial associative task at either test interval. In contrast, a deficit was observed on a spatial memory task (forced-choice alternation t-maze) for animals with combined lesions of the hippocampus and subiculum. These results contradict the findings of Bunsey and Eichenbaum (1995) and support the idea that the hippocampus/subicular region is not required for this nonspatialassociative memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:15:39