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Titolo:
VMAT-Mediated changes in quantal size and vesicular volume
Autore:
Colliver, TL; Pyott, SJ; Achalabun, M; Ewing, AG;
Indirizzi:
Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 2, University Pk, PA 16802 USA Penn State Univ, Dept Anat & Neurosci, Coll Med, Hershey, PA 17033 USA Penn State Univ Hershey PA USA 17033 sci, Coll Med, Hershey, PA 17033 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 20, anno: 2000,
pagine: 5276 - 5282
SICI:
0270-6474(20000715)20:14<5276:VCIQSA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADRENAL CHROMAFFIN CELLS; PHEOCHROMOCYTOMA PC12 CELLS; NERVE GROWTH-FACTOR; RAT PHEOCHROMOCYTOMA; SECRETORY GRANULES; MEDULLARY CELLS; OSMOTIC-PRESSURE; DOPAMINE RELEASE; MEMBRANE-FUSION; CHROMOGRANIN-A;
Keywords:
vesicular monoamine transporter; amperometry; transmission electron microscopy; PC12 cells; quantal size; vesicle volume;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Ewing, AG Penn State Univ, Dept Chem, Davey Lab 152, University Pk, PA 16802 USA Penn State Univ University Pk PA USA 16802 ity Pk, PA 16802 USA
Citazione:
T.L. Colliver et al., "VMAT-Mediated changes in quantal size and vesicular volume", J NEUROSC, 20(14), 2000, pp. 5276-5282

Abstract

It has been well established that the volume of secretory vesicles can be modulated. However, we present the first data demonstrating that the amountof transmitter in a vesicle can regulate its volume. Amperometry and transmission electron microscopy have been used to determine that L-3,4-dihydroxyphenylalanine and reserpine increase and decrease, respectively, the volume of single pheochromocytoma cell vesicles as well as their catecholamine content. Because changes in vesicular catecholamine content are tracked by changes in vesicle volume, our results indicate that when quantal size is altered via the vesicular monoamine transporter the concentration of catecholamines within the vesicles remains relatively constant. This previously unidentified cellular response provides new insight into how catecholamines can be packaged in and released from secretory vesicles.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 23:59:30