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Titolo:
The regulatory connection between the activity of granule cell NMDA receptors and dendritic differentiation of cerebellar Purkinje cells
Autore:
Hirai, H; Launey, T;
Indirizzi:
RIKEN, Brain Sci Inst, Lab Memory & Learning, Wako, Saitama 3510198, JapanRIKEN Wako Saitama Japan 3510198 & Learning, Wako, Saitama 3510198, Japan
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 14, volume: 20, anno: 2000,
pagine: 5217 - 5224
SICI:
0270-6474(20000715)20:14<5217:TRCBTA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NITRIC-OXIDE SYNTHASE; NEUROTROPHIC FACTOR; ELECTRICAL-ACTIVITY; RAT CEREBELLUM; SURVIVAL; NEURONS; EXPRESSION; BDNF; CULTURE;
Keywords:
Purkinje cell; granule cell; NMDA receptor; BDNF; TrkB; development;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Hirai, H RIKEN, Brain Sci Inst, Lab Memory & Learning, Wako, Saitama 3510198, Japan RIKEN Wako Saitama Japan 3510198 g, Wako, Saitama 3510198, Japan
Citazione:
H. Hirai e T. Launey, "The regulatory connection between the activity of granule cell NMDA receptors and dendritic differentiation of cerebellar Purkinje cells", J NEUROSC, 20(14), 2000, pp. 5217-5224

Abstract

It is known that cerebellar granule cells are powerful inducers for the differentiation of Purkinje cells. However, the detailed mechanism of this regulation has not yet been clarified. Here, using cerebellar neuronal culture, we show that the activation of NMDA receptors expressed by granule cellstriggers the signaling pathway for the dendritic differentiation of Purkinje cells. This signal has been shown to promote the granule cell survival through BDNF-mediated TrkB activation, leading to Purkinje cell differentiation by increasing the granule-Purkinje cell interaction. Among the possiblesignal molecules provided to the dendrites of Purkinje cells from granule cells, nitric oxide was found to have no effect on the dendritic outgrowth and branching, but electrical activity and the subsequent intracellular Ca2 increase were thought to play an important role in the branching and thickening of the dendrites, because blockade of both non-NMDA and metabotropicglutamate receptors caused a significant decrease in the number of branch points and the diameter of Purkinje dendrites without apparently affecting the dendrite extension and spine formation. Collectively, these results suggest that Purkinje cell differentiation is regulated by two successive steps. The first step is initiated by the NMDA receptor-mediated signal in granule cells, which acts as a trophic factor for granule cells. The second step involves the activation of granule-Purkinje synapses, providing neurotrophic substances and electrical activity essential for Purkinje cell differentiation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:57:26