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Titolo:
CINITAPRIDE PROTECTS AGAINST ETHANOL-INDUCED GASTRIC-MUCOSAL INJURY IN RATS - ROLE OF 5-HYDROXYTRYPTAMINE, PROSTAGLANDINS AND SULFHYDRYL COMPOUNDS
Autore:
ROMERO CA; LOPEZ A; MARTIN MJ; LACASA C; MOTILVA V;
Indirizzi:
UNIV SEVILLA,FAC FARM,DEPT FARM & TECNOL FARMACEUT,LAB FARMACODINAM,CPROF GARCIA GONZALEZ S-N E-41012 SEVILLE SPAIN
Titolo Testata:
Pharmacology
fascicolo: 4, volume: 54, anno: 1997,
pagine: 193 - 202
SICI:
0031-7012(1997)54:4<193:CPAEGI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-FLOW; ZINC ACEXAMATE; DAMAGE; MECHANISMS; SEROTONIN; ACID; ULCERATION; INHIBITION; CISAPRIDE; MOTILITY;
Keywords:
CINITAPRIDE; 5-HYDROXYTRYPTAMINE; GASTRIC ULCERATION; PROSTAGLANDINS; SULFHYDRYL COMPOUNDS; GASTRIC MUCUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Romero et al., "CINITAPRIDE PROTECTS AGAINST ETHANOL-INDUCED GASTRIC-MUCOSAL INJURY IN RATS - ROLE OF 5-HYDROXYTRYPTAMINE, PROSTAGLANDINS AND SULFHYDRYL COMPOUNDS", Pharmacology, 54(4), 1997, pp. 193-202

Abstract

This study was designed to determine the gastroprotective properties of cinitapride (CNT), a novel prokinetic benzamide derivative agonist of 5-HT4 and 5-HT1 receptors and 5-HT2 antagonist, on mucosal injury produced by 50% (v/v) ethanol. Results were compared with those for 5-hydroxytryptamine (5-HT: 10 mg kg(-1)). The possible involvements of gastric mucus secretion, endogenous prostaglandins (PGs) and sulfhydryl compounds (SH) in the protection mediated by CNT were also examined. Intraperitoneal administration of CNT (0.50 and 1 mg kg(-1)), 30 min before ethanol, significantly prevented gastric ulceration and increasedthe hexosamine content of gastric mucus. CNT (1 mg kg(-1)) also produced a significant increase in gastric mucosal levels of PGE(2), but did not induce any significant changes in SH values. On the contrary, pretreatment with 5-HT worsened ethanol-induced erosions, however, did not affect gastric mucus secretion, glycoprotein content or PGE(2) levels, although the non-protein SH fraction was significantly decreased. The present results demonstrate that the gastroprotective effects of CNT could be partly explained by a complex PG dependent mechanism. We suggest that 5-HT dependent mechanisms through 5-HT2 receptor blockade and 5-HT1 receptor activation could be also involved.

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Documento generato il 02/12/20 alle ore 04:05:54