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Titolo:
Diagnosis and surveillance of herpes simplex virus infection of the central nervous system
Autore:
Najioullah, F; Bosshard, S; Thouvenot, D; Boibieux, A; Menager, B; Biron, F; Aymard, M; Lina, B;
Indirizzi:
Virol Lab, F-69373 Lyon 08, France Virol Lab Lyon France 08Virol Lab, F-69373 Lyon 08, France Hop Croix Rousse, Serv Malad Infect & Trop, F-69317 Lyon, France Hop CroixRousse Lyon France F-69317 Infect & Trop, F-69317 Lyon, France Hop Debrousse, Serv Pediat, Lyon, France Hop Debrousse Lyon FranceHop Debrousse, Serv Pediat, Lyon, France
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 4, volume: 61, anno: 2000,
pagine: 468 - 473
SICI:
0146-6615(200008)61:4<468:DASOHS>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE-CHAIN-REACTION; CEREBROSPINAL-FLUID; REACTION ASSAY; ENCEPHALITIS; DNA; MENINGITIS; TYPE-2; PCR; ACYCLOVIR;
Keywords:
polymerase chain reaction; HSV1; HSV2; encephalitis; aseptic meningitis; prevalence;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Najioullah, F Virol Lab, Domaine Rockefeller, F-69373 Lyon 08, France Virol Lab Domaine Rockefeller Lyon France 08 yon 08, France
Citazione:
F. Najioullah et al., "Diagnosis and surveillance of herpes simplex virus infection of the central nervous system", J MED VIROL, 61(4), 2000, pp. 468-473

Abstract

Herpes simplex viruses (HSV) are responsible for neurological disorders that require rapid diagnostic methods and specific antiviral therapy. During 1997, 1431 cerebrospinal fluid samples (CSF) collected from 1339 patients with neurological disorder presentations were processed for HSV detection. Eleven patients were positive for HSV, seven presenting with encephalitis (6/7 due to HSV1) and 4 with aseptic meningitis (4/4 due to HSV2). The incidence of HSV encephalitis was 2.33 cases / 10(6) inhabitants/ year. Among encephalitis (HSV encephalitis) cases, 1 patient died due to the late implementation of antiviral therapy, and sequelae were observed in 4 cases. No sequelae were observed in aseptic meningitis cases. Four HSV encephalitis caseswere monitored by PCR detection in CSF. Despite acyclovir therapy, PCR remained positive in CSF up to 20 days in 2 cases. This result suggest that the antiviral treatment for HSV encephalitis should be monitored by PCR detection of HSV in CSF. J. Med. Virol. 61:468-4 73, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 10:05:46