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Titolo:
Chlamydia pneumoniae and atherosclerotic risk in populations: The role of seroepidemiology
Autore:
Siscovick, DS; Schwartz, SM; Caps, M; Wang, SP; Grayston, JT;
Indirizzi:
Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98101 USAUniv Washington Seattle WA USA 98101 nit, Dept Med, Seattle, WA 98101 USA Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol, Seattle, WA 98101 USA Univ Washington Seattle WA USA 98101 ept Epidemiol, Seattle, WA 98101 USA Univ Washington, Cardiovasc Hlth Res Unit, Dept Pathobiol, Seattle, WA 98101 USA Univ Washington Seattle WA USA 98101 ept Pathobiol, Seattle, WA 98101 USA Univ Washington, Cardiovasc Hlth Res Unit, Dept Surg, Seattle, WA 98101 USA Univ Washington Seattle WA USA 98101 it, Dept Surg, Seattle, WA 98101 USA Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA Fred Hutchinson Canc Res Ctr Seattle WA USA 98104 , Seattle, WA 98104 USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
, volume: 181, anno: 2000, supplemento:, 3
pagine: S417 - S420
SICI:
0022-1899(200006)181:<S417:CPAARI>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; HEART-DISEASE; STRAIN TWAR; MYOCARDIAL-INFARCTION; CAROTID-ARTERY; INFECTION; PATHOGENESIS; ASSOCIATION; MECHANISMS; MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Siscovick, DS Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, MetropolitanPk E Tower,1730 Minor Ave,Suite 1360, Seattle, WA 98101 USA Univ Washington MetropolitanPk E Tower,1730 Minor Ave,Suite 1360 Seattle WA USA 98101
Citazione:
D.S. Siscovick et al., "Chlamydia pneumoniae and atherosclerotic risk in populations: The role of seroepidemiology", J INFEC DIS, 181, 2000, pp. S417-S420

Abstract

While seroepidemiologic studies first suggested a possible association of prior infection with Chlamydia pneumoniae and atherosclerotic risk, the contribution of seroepidemiologic studies of C. pneumoniae and atheroscleroticrisk remains a source of controversy, in part because the reported findings appear inconsistent. In general, cross-sectional studies of C. pneumoniaeand atherosclerotic risk suggest an association, but recent reports from several prospective studies failed to demonstrate associations between the presence of IgG antibodies to C. pneumoniae and incident myocardial infarction. Evidence from other paradigms-pathologic, animal experimental, and molecular studies-supports a possible etiologic role for C. pneumoniae in atherothrombotic disease, raising questions about the contribution of seroepidemiologic studies. This review summarizes the major findings from seroepidemiologic studies in the context of other research paradigms, explores alternative explanations for the inconsistent findings, and suggests a further role for seroepidemiologic studies of C. pneumoniae and atherothrombotic risk.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 05:29:39