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Titolo:
Hypothalamic-pituitary-adrenal activity and pro-opiomelanocortin mRNA levels in the hypothalamus and pituitary of the rat are differentially modulated by acute intermittent morphine with or without water restriction stress
Autore:
Zhou, Y; Spangler, R; Maggos, CE; Wang, XM; Han, JS; Ho, A; Kreek, MJ;
Indirizzi:
Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10021 USA Rockefeller Univ New York NY USA 10021 Addict Dis, New York, NY 10021 USA Beijing Med Univ, Neurosci Res Inst, Beijing 100083, Peoples R China Beijing Med Univ Beijing Peoples R China 100083 100083, Peoples R China
Titolo Testata:
JOURNAL OF ENDOCRINOLOGY
fascicolo: 2, volume: 163, anno: 1999,
pagine: 261 - 267
SICI:
0022-0795(199911)163:2<261:HAAPML>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; ACTH-SECRETION; MESSENGER-RNA; PHARMACOLOGICAL CHARACTERIZATION; OPIOID INHIBITION; GENE-EXPRESSION; OPIATE AGONISTS; BETA-ENDORPHIN; COCAINE; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Zhou, Y Rockefeller Univ, Lab Biol Addict Dis, 1230 York Ave, New York, NY10021 USA Rockefeller Univ 1230 York Ave New York NY USA 10021 NY 10021 USA
Citazione:
Y. Zhou et al., "Hypothalamic-pituitary-adrenal activity and pro-opiomelanocortin mRNA levels in the hypothalamus and pituitary of the rat are differentially modulated by acute intermittent morphine with or without water restriction stress", J ENDOCR, 163(2), 1999, pp. 261-267

Abstract

Acute administration of morphine stimulates the secretion of hypothalamic-pituitary-adrenal (HPA) hormones, ACTH. beta-endorphin and corticosterone in the rat. In this study we investigated the effects of repeated multiple-dose morphine on HPA activity under two different conditions: without or with water restriction stress. Rats received six intermittent injections of morphine (6.25 mg/kg per injection, s.c.) every 2 h and were killed 30 min after the last injection. The results were as follows. (1) Morphine significantly elevated plasma ACTH and corticosterone levels; water restriction also significantly increased ACTH secretion, but with no significant increase of plasma corticosteronelevels. In contrast, rats treated with morphine under the water restriction condition failed to show any increases of either ACTH or corticosterone levels. (2) Morphine did not change pro-opiomelanocortin (POMC) mRNA levels in the anterior pituitary; whereas water restriction significantly increased the POMC mRNA levels. The water restriction-induced increases of POMC mRNA in the anterior pituitary were absent in the rats which received morphine. (3) Morphine significantly increased POMC mRNA levels in the hypothalamus; water restriction had no effect. The morphine-induced increases in POMC mRNA in the hypothalamus were absent in the rat under the water restriction condition. These findings, that the effects of morphine on HPA activation or POMC mRNA expression depend on the presence of stress, suggest a counter-regulatoryrole of opiates on a stress response and opioid gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:57:28