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Titolo:
Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression: A survey of current "next-step" practices
Autore:
Fredman, SJ; Fava, M; Kienke, AS; White, CN; Nierenberg, AA; Rosenbaum, JF;
Indirizzi:
Massachusetts Gen Hosp, Mood & Anxiety Disorders Program, Boston, MA 02114USA Massachusetts Gen Hosp Boston MA USA 02114 s Program, Boston, MA 02114USA Massachusetts Gen Hosp, Depress Clin & Res Program, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Program, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 vard Univ, Sch Med, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF CLINICAL PSYCHIATRY
fascicolo: 6, volume: 61, anno: 2000,
pagine: 403 - 408
SICI:
0160-6689(200006)61:6<403:PRNARW>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
TREATMENT-RESISTANT DEPRESSION; ONE ANTIDEPRESSANT FAILS; FLUOXETINE TREATMENT; PSYCHIATRISTS; AUGMENTATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Rosenbaum, JF Massachusetts Gen Hosp, Dept Psychiat, 15 Parkman St,WAC 812, Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St,WAC 812 Boston MA USA 02114
Citazione:
S.J. Fredman et al., "Partial response, nonresponse, and relapse with selective serotonin reuptake inhibitors in major depression: A survey of current "next-step" practices", J CLIN PSY, 61(6), 2000, pp. 403-408

Abstract

Background: Many patients treated for major depression require more than one antidepressant trial to achieve or sustain response However, the literature provides few treatment algorithms or effectiveness studies that empirically support "next-step" options available to clinicians. We conducted a sun ey of psychiatrists and other medical specialists who treat depression toascertain what clinicians actually do when faced with patients who suboptimally respond to an adequate course of selective serotonin reuptake inhibitor (SSRI) therapy. Method: Attendees at a psychopharmacology course (N = 801) were queried about their top choices for antidepressant-treatment nonresponders: a minimalresponder after 4 weeks of adequate SSRI treatment, a partial responder after 8 weeks of adequate SSRI therapy, a nonresponder after 8 weeks of adequate SSRI therapy, and a relapser on long-term SSRI maintenance therapy, Choices included raising the dose, augmenting or combining with another agent,switching to a second SSRI, or switching to a non-SSRI agent. Results: 432 (54%) of the surveys were returned. Raising the dose was the most frequently reported next-step strategy for a patient with minimal response after if weeks of adequate SSRI therapy, partial response after 8 weeks of adequate SSRI therapy, and relapse on long-term SSRI therapy. Switching to a non-SSRI agent was the most frequently chosen option for nonresponders to an adequate trial of SSRI therapy. Conclusion: Our findings suggest that clinicians select different next-step strategies when patients are nonresponders versus when patients are partial responders or relapsers.

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Documento generato il 22/09/20 alle ore 14:21:13