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Titolo:
Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-C-11]WAY-100635 in humans: Comparison of arterial and reference tissue input functions
Autore:
Parsey, RV; Slifstein, M; Hwang, DR; Abi-Dargham, A; Simpson, N; Mawlawi, O; Guo, NN; Van Heertum, R; Mann, JJ; Laruelle, M;
Indirizzi:
New York State Psychiat Inst, Unit 42, Dept Neurosci, Div Brain Imaging, New York, NY 10032 USA New York State Psychiat Inst New York NY USA 10032 New York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Radiol, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA
Titolo Testata:
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
fascicolo: 7, volume: 20, anno: 2000,
pagine: 1111 - 1133
SICI:
0271-678X(200007)20:7<1111:VAROMO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; HUMAN BRAIN; C-11 RACLOPRIDE; H-3 WAY-100635; BINDING-SITES; PET; MODEL; RADIOLIGAND; RAT; SCHIZOPHRENIA;
Keywords:
positron emission tomography; serotonin; 5-HT1A receptors; [C-11]WAY 100635;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Parsey, RV New York State Psychiat Inst, Unit 42, Dept Neurosci, Div BrainImaging, 1051 Riverside Dr, New York, NY 10032 USA New York State PsychiatInst 1051 Riverside Dr New York NY USA 10032
Citazione:
R.V. Parsey et al., "Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-C-11]WAY-100635 in humans: Comparison of arterial and reference tissue input functions", J CEREBR B, 20(7), 2000, pp. 1111-1133

Abstract

Serotonin 5-HT1A receptors are implicated in the pathophysiology of neuropsychiatric conditions. The goal of this study was to evaluate methods to derive 5-HT1A receptor parameters in the human brain with positron emission tomography (PET) and [carborzyl-C-11]WAY 100635. Five healthy volunteer subjects were studied twice. Three methods of analysis were used to derive the binding potential (BP), and the specific to nonspecific equilibrium partition coefficient (k(3)/k(4)). Two methods, kinetic analysis based on a three compartment model and graphical analysis, used the arterial plasma time-activity curves as the input function to derive BP and k(3)/k(4). A third method, the simplified reference tissue model (SRTM), derived the input function from uptake data of a region of reference, the cerebellum, and provided only k(3)/k(4). All methods provided estimates of regional 5-HT1A receptor parameters that were highly correlated. Results were consistent with the known distribution of 5-HT1A receptors in the human brain. Compared with kinetic BP, graphical analysis slightly underestimated BP, and this phenomenon was mostly apparent in mall size-high noise regions. Compared with kinetic k(3)/k(4), the reference tissue method underestimated k,flc, and the underestimation was apparent primarily in regions with high receptor density. Derivation of BP by both kinetic and graphical analysis was highly reliable, with an intraclass correlation coefficient (ICC) of 0.84 +/- 0.14 (mean +/- SD of 15 regions) and 0.84 +/- 0.19, respectively. In contrast, the reliability of k(3)/k(4) was lower, with ICC of 0.53 +/- 0.28, 0.47 +/- 0.28, and 0.55 +/- 0.29 for kinetic, graphical, and reference tissue methods, respectively. In conclusion, derivation of BP by kinetic analysis using the arterial plasma input function appeared as the method of choice because of its higher test-retest reproducibility, lower vulnerability to experimental noise,and absence of bias.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:17:09