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Titolo:
Plasma-treated PET surfaces improve the biocompatibility of human endothelial cells
Autore:
Ramires, PA; Mirenghi, L; Romano, AR; Palumbo, F; Nicolardi, G;
Indirizzi:
Ctr Nazl Ric & Sviluppo Mat, CNRSM, PASTIS, I-72100 Brindisi, Italy Ctr Nazl Ric & Sviluppo Mat Brindisi Italy I-72100 72100 Brindisi, Italy Univ Lecce, Dept Biol, I-73100 Lecce, Italy Univ Lecce Lecce Italy I-73100 iv Lecce, Dept Biol, I-73100 Lecce, Italy Univ Bari, Dept Chem, Bari, Italy Univ Bari Bari ItalyUniv Bari, Dept Chem, Bari, Italy
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 3, volume: 51, anno: 2000,
pagine: 535 - 539
SICI:
0021-9304(20000905)51:3<535:PPSITB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADHESION; POLYMERS; GROWTH; POLYTETRAFLUOROETHYLENE; ADSORPTION; DEPOSITION; DACRON; AMINE; AMIDE;
Keywords:
plasma treatments; polyethyleneterephthalate; endothelial cells; biocompatibility tests; vascular grafts;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Ramires, PA Ctr Nazl Ric & Sviluppo Mat, CNRSM, PASTIS, SS 7 Appia,Km 714,I-72100 Brindisi, Italy Ctr Nazl Ric & Sviluppo Mat SS 7 Appia,Km 714 Brindisi Italy I-72100
Citazione:
P.A. Ramires et al., "Plasma-treated PET surfaces improve the biocompatibility of human endothelial cells", J BIOMED MR, 51(3), 2000, pp. 535-539

Abstract

Failures of small internal diameter vascular grafts have been caused by the lack of a stable endothelial lining to form on their artificial surfaces. Polymer surfaces can be optimized by means of proper treatment to allow a homogeneous and uniform coverage in artificial prosthesis applications. Several solutions were studied to improve cell attachment and growth on artificial materials. Ln the present study, polyethyleneterephthalate (PET) surfaces were treated by plasma processes with oxygen and ammonia and also in the presence of a gas mixture to verify the effect of functional groups grafting onto the endothelial cell growth. Related surface chemical modifications were investigated by X-ray photoelectron spectroscopy (XPS). Then using cytotoxicity and cytocompatibility tests, the biocompatibility of the modified PET surfaces was assessed by studying the behavior of human umbilical vein endothelial cells (HUVEC). The results showed that plasma-treated PET samples have no toxic effect on HUVEC. The cytocompatibility tests revealed an increase in cell growth with incubation time and the presence of well-spread and flattened cells (SEM analyses). Thus it is reported that plasma treatments can improve PET biocompatibility to HUVEC. (C) 2000 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/01/21 alle ore 22:27:12