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Titolo:
Peptoid-containing collagen mimetics with cell binding activity
Autore:
Johnson, G; Jenkins, M; McLean, KM; Griesser, HJ; Kwak, J; Goodman, M; Steele, JG;
Indirizzi:
Cooperat Res Ctr Eye Res & Technol, N Ryde, NSW 1670, Australia Cooperat Res Ctr Eye Res & Technol N Ryde NSW Australia 1670 0, Australia CSIRO Mol Sci, N Ryde, NSW 1670, Australia CSIRO Mol Sci N Ryde NSW Australia 1670 Sci, N Ryde, NSW 1670, Australia CSIRO Mol Sci, Clayton, Vic 3169, Australia CSIRO Mol Sci Clayton Vic Australia 3169 ci, Clayton, Vic 3169, Australia Univ Calif San Diego, Dept Biochem & Chem, La Jolla, CA 92093 USA Univ Calif San Diego La Jolla CA USA 92093 & Chem, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 4, volume: 51, anno: 2000,
pagine: 612 - 624
SICI:
0021-9304(20000915)51:4<612:PCMWCB>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
N-ISOBUTYLGLYCINE NLEU; CORNEAL EPITHELIAL-CELLS; HELICAL PEPTIDE MODELS; SMOOTH-MUSCLE CELLS; IV COLLAGEN; ALPHA-2-BETA-1 INTEGRIN; CONFORMATIONAL-ANALYSIS; ATTACHMENT ACTIVITY; CIRCULAR-DICHROISM; OPTICAL-ROTATION;
Keywords:
collagen mimetics; peptoids; cell binding peptides; corneal epithelial cells; alpha 2 beta 1 integrin receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Johnson, G Cooperat Res Ctr Eye Res & Technol, POB 184, N Ryde, NSW 1670, Australia Cooperat Res Ctr Eye Res & Technol POB 184 N Ryde NSW Australia 1670
Citazione:
G. Johnson et al., "Peptoid-containing collagen mimetics with cell binding activity", J BIOMED MR, 51(4), 2000, pp. 612-624

Abstract

Collagen mimetic peptides containing the peptoid residue Nleu (Goodman Bhumralkar, Jefferson, Kwak, Locardi. Biopolymers 1998;47:127-142) were testedfor interactions with epithelial cells and fibroblasts. Molecules containing the sequence Gly-Pro-Nleu with a minimum of nine repeats showed cell binding activity. The activity of these molecules appeared to be conformationally sensitive, with the triple-helical form being preferred. When immobilized on a surface, the (Gly-Pro-Nleu)(10)-Gly-Pro-NH2 sequence stimulated theattachment and growth of corneal epithelial cells and fibroblasts and the migration of epithelial tissue. The peptide sequence KDGEA inhibited cell attachment to the (Gly-Pro-Nleu)(10)-Gly-Pro-NH2 sequence, suggesting that cell binding to this collagen mimetic involves the alpha 2 beta 1 heterodimer integrin receptor. Interestingly, peptides containing the sequence (GlyNleu-Pro-)(10)-NH2 did not have cell binding activity. The discovery that triple-helical peptides containing the Gly-Pro-Nleu sequences interact with cells opens up new opportunities in the design of collagen mimetic biomaterials. (C) 2000 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 07:10:56