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Titolo:
Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers
Autore:
Russell, PA; Pharoah, PDP; De Foy, K; Ramus, SJ; Symmonds, I; Wilson, A; Scott, I; Ponder, BAJ; Gayther, SA;
Indirizzi:
Strangeways Res Lab, CRC Oncol, Cambridge CB1 8RN, England Strangeways ResLab Cambridge England CB1 8RN Cambridge CB1 8RN, England Derby City Gen Hosp, Acad Dept Obstet & Gynaecol, Derby, England Derby City Gen Hosp Derby England ept Obstet & Gynaecol, Derby, England Derby City Gen Hosp, Oncol Res Lab, Derby, England Derby City Gen Hosp Derby England n Hosp, Oncol Res Lab, Derby, England
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 3, volume: 87, anno: 2000,
pagine: 317 - 321
SICI:
0020-7136(20000801)87:3<317:FLOBMA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; BREAST-CANCER; SUBCELLULAR-LOCALIZATION; NUCLEAR PHOSPHOPROTEIN; GERMLINE MUTATIONS; CPG METHYLATION; PROMOTER; REGION; CELLS; PROGRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Russell, PA Strangeways Res Lab, CRC Oncol, Worts Causeway, Cambridge CB1 8RN, England Strangeways Res Lab Worts Causeway Cambridge England CB1 8RN
Citazione:
P.A. Russell et al., "Frequent loss of BRCA1 mRNA and protein expression in sporadic ovarian cancers", INT J CANC, 87(3), 2000, pp. 317-321

Abstract

Germline mutations in the BRCAI gene cause inherited susceptibility to breast and ovarian cancers. However, somatic mutations of BRCAI are rare in sporadic breast and ovarian tumours. To establish whether BRCAI is altered during the development of sporadic ovarian cancer by mechanisms other than somatic mutation, we have analysed 57 sporadic epithelial ovarian tumours forBRCAI protein and RNA expression. Reduced or absent protein expression wasobserved in 90% of tumours. Decreased protein expression was significantlyassociated with a reduction in the levels of RNA expression. Somatic mutations of BRCAI and LOH at the BRCAI locus were detected in 3.5% and 44% of informative tumours, respectively; there was no significant correlation between the levels of protein and RNA expression and the DNA mutation and/or LOH status. Together, these data suggest that expression of BRCAI is down-regulated at the level of transcription during the development of sporadic ovarian cancers. Int. J. Cancer 87:317-321, 2000. (C) 2000 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 07:09:06