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Titolo:
High frequency of circulating gamma delta T cells with dominance of the V(delta)1 subset in a healthy population
Autore:
Hviid, L; Akanmori, BD; Loizon, S; Kurtzhals, JAL; Ricke, CH; Lim, A; Koram, KA; Nkrumah, FK; Mercereau-Puijalon, O; Behr, C;
Indirizzi:
Copenhagen Univ Hosp, Rigshosp, Dept Infect Dis, Ctr Med Parasitol, DK-2000 Copenhagen, Denmark Copenhagen Univ Hosp Copenhagen Denmark DK-2000 2000 Copenhagen, Denmark Univ Copenhagen, Inst Med Microbiol & Immunol, DK-2000 Copenhagen, DenmarkUniv Copenhagen Copenhagen Denmark DK-2000 , DK-2000 Copenhagen, Denmark Univ Ghana, Noguchi Mem Inst Med Res, Immunol Unit, Legon, Ghana Univ Ghana Legon Ghana chi Mem Inst Med Res, Immunol Unit, Legon, Ghana Univ Ghana, Noguchi Mem Inst Med Res, Epidemiol Unit, Legon, Ghana Univ Ghana Legon Ghana i Mem Inst Med Res, Epidemiol Unit, Legon, Ghana Inst Pasteur, Unite Biol Mol Gene, F-75724 Paris, France Inst Pasteur Paris France F-75724 e Biol Mol Gene, F-75724 Paris, France Inst Pasteur, Unite Immunol Mol Parasites, CNRS, URA 1960, F-75724 Paris, France Inst Pasteur Paris France F-75724 CNRS, URA 1960, F-75724 Paris, France
Titolo Testata:
INTERNATIONAL IMMUNOLOGY
fascicolo: 6, volume: 12, anno: 2000,
pagine: 797 - 805
SICI:
0953-8178(200006)12:6<797:HFOCGD>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMODIUM-FALCIPARUM MALARIA; PERIPHERAL-BLOOD LYMPHOCYTES; CD8 ACCESSORY MOLECULE; MONOCLONAL-ANTIBODIES; ANTIGEN RECEPTOR; CD38 MOLECULE; EXPRESSION; GAMMA/DELTA; STIMULATION; REPERTOIRE;
Keywords:
age; CDR3; Epstein-Barr virus; gamma delta T cells; malaria; T cell repertoire; V(delta)1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Hviid, L Rigshosp, Dept Infect Dis M7641, Tagensvej 20, DK-2200 CopenhagenN, Denmark Rigshosp Tagensvej 20 Copenhagen Denmark N Copenhagen N, Denmark
Citazione:
L. Hviid et al., "High frequency of circulating gamma delta T cells with dominance of the V(delta)1 subset in a healthy population", INT IMMUNOL, 12(6), 2000, pp. 797-805

Abstract

TCR gamma delta(+) cells constitute <5% of all circulating T cells in healthy, adult Caucasians, and V(delta)1(+) cells constitute a minority of these cells. In contrast to TCR alpha beta(+) cells, their repertoire is selected extrathymically by environmental antigens, Although increased frequencies of V(delta)1(+) cells are found in several diseases, their function remains obscure. Here we show that the frequency of peripheral blood gamma deltaT cells in healthy West Africans is about twice that of Caucasians, mainlydue to a 5-fold increase in V(delta)1(+) cells, which is consequently the dominant subset. No age dependency of V(delta)1 frequencies was identified and the V(delta)1(+) cells in the African donors did not show preferential V-gamma chain usage. Analysis of the CDR3 region size did not reveal any particular skewing of the V(delta)1 repertoire, although oligoclonality was more pronounced in adults compared to children. The proportions of CD8(+), CD38(+) and CD45RA(hi)CD45RO(-) cells within the V(delta)1(+) subset were higher in the African than in the European donors, without obvious differences in expression of activation markers, No significant correlations between levels of V(delta)1(+) cells and environmental antigens or immunological parameters were identified. Taken together, the evidence argues against a CDR3-restricted, antigen-driven expansion of V(delta)1(+) cells in the Africanstudy population. Our study shows that high frequencies of TCR gamma delta(+) cells with dominance of the V(delta)1(+) subset can occur at the population level in healthy people, raising questions about the physiological role of V(delta)1(+) T cells in the function and regulation of the immune system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:45:36