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Titolo:
Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine
Autore:
Yoshimura, R; Ueda, N; Nakamura, J;
Indirizzi:
Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555 8555, Japan
Titolo Testata:
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 15, anno: 2000,
pagine: 233 - 235
SICI:
0268-1315(200007)15:4<233:LDOLDN>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIQUID-CHROMATOGRAPHIC DETERMINATION; PHARMACOKINETICS; METABOLITES;
Keywords:
fluvoxamine; levomepromazine; plasma concentration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Yoshimura, R Univ Occupat & Environm Hlth, Sch Med, Dept Psychiat, Yahatanishi Ku, Kitakyushu, Fukuoka 8078555, Japan Univ Occupat & Environm Hlth Kitakyushu Fukuoka Japan 8078555
Citazione:
R. Yoshimura et al., "Low dosage of levomepromazine did not increase plasma concentrations of fluvoxamine", INT CLIN PS, 15(4), 2000, pp. 233-235

Abstract

The cytochrome enzyme P450 2D6 (CYP2D6) is thought to play a role in the human metabolism of fluvoxamine. Levomepromazine is a potent inhibitor of CYP2D6. We coadministered a low dosage of levomepromazine and fluvoxamine in 15 patients and found that the low dosage of levomepromazine was effective in counteracting the fluvoxamine-induced insomnia and did not increase plasma fluvoxamine levels. These results suggest that the inhibition of CYP2D6 by levomepromazine has little effect on fluvoxamine metabolism. Therefore, a low dosage of levomepromazine, used as a hypnotic agent, appears to be effective and safe when coadministered with fluvoxamine. Since this was a pilot study without a placebo control, a double-blind placebo-controlled studyis needed to confirm our preliminary findings. int Clin Psychopharmocol 15:233-235 (C) 2000 Lippincott Williams & Wilkins.

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Documento generato il 25/01/20 alle ore 19:07:46